methacrylyl-CoA + H2O <=> beta-hydroxyisobutyryl-CoA

Stable Identifier
R-HSA-70870
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
methacrylyl-CoA + H2O <=> beta-hydroxyisobutyryl-CoA
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The reversible reaction of methacrylyl-CoA and water to form beta-hydroxybutyryl-CoA takes place in the mitochondrial matrix. While crude extracts of human fibroblasts and liver cells have been shown to catalyze the reaction, the specific human enzyme responsible for it has not been identified.

Literature References
PubMed ID Title Journal Year
  The Metabolic and Molecular Bases of Inherited Disease, 8th ed

Scriver, CR, Beaudet, AL, Valle, D, Sly, WS

  2001
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
enoyl-CoA hydratase activity of enoyl-CoA hydratase [mitochondrial matrix]
Physical Entity
enoyl-CoA hydratase [mitochondrial matrix]
Activity
enoyl-CoA hydratase activity (0004300)
Cross References
Rhea