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ACAT1(35-427) [mitochondrial matrix]
Stable Identifier
R-HSA-70838
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
acetyl-CoA acetyltransferase, Acetyl-CoA acetyltransferase, mitochondrial, Acetoacetyl-CoA thiolase, ACAT1
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of amino acids and derivatives (Homo sapiens)
Branched-chain amino acid catabolism (Homo sapiens)
alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Homo sapiens)
ACAT1 tetramer [mitochondrial matrix] (Homo sapiens)
ACAT1(35-427) [mitochondrial matrix] (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Ketone body metabolism (Homo sapiens)
Synthesis of Ketone Bodies (Homo sapiens)
2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Homo sapiens)
ACAT1 tetramer [mitochondrial matrix] (Homo sapiens)
ACAT1(35-427) [mitochondrial matrix] (Homo sapiens)
Utilization of Ketone Bodies (Homo sapiens)
acetoacetyl-CoA + CoA <=> 2 acetyl-CoA (Homo sapiens)
ACAT1 tetramer [mitochondrial matrix] (Homo sapiens)
ACAT1(35-427) [mitochondrial matrix] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
17371050
Crystallographic and kinetic studies of human mitochondrial acetoacetyl-CoA thiolase: the importance of potassium and chloride ions for its structure and function
Kondo, N
,
Haapalainen, AM
,
Fukao, T
,
Pirilä, PL
,
Wierenga, RK
,
Meriläinen, G
Biochemistry
2007
External Reference Information
External Reference
UniProt:P24752 ACAT1
Gene Names
ACAT1, ACAT, MAT
Chain
transit peptide:1-33, chain:34-427
Reference Genes
BioGPS Gene:38 ACAT1
COSMIC (genes):ACAT1 ACAT1
CTD Gene:38 ACAT1
dbSNP Gene:38 ACAT1
ENSEMBL:ENSG00000075239 ACAT1
ENSEMBL:ENSG00000075239.14 ACAT1
HGNC:93 ACAT1
KEGG Gene (Homo sapiens):38 ACAT1
Monarch:38 ACAT1
NCBI Gene:38 ACAT1
OMIM:607809 ACAT1
UCSC:P24752 ACAT1
Reference Transcript
RefSeq:NM_000019.3 ACAT1
Other Identifiers
11742973_at
11761280_at
1554947_PM_at
1554947_at
205412_PM_at
205412_at
3347617
3347618
3347626
3347628
3347629
3347630
3347631
3347632
3347633
3347634
3347636
3347638
3347639
3347641
3347644
3347645
3347646
38
39678_at
7943605
A_14_P104456
A_23_P24515
A_24_P203678
A_33_P3253975
D10511_at
GE60478
GO:0001889
GO:0003824
GO:0003985
GO:0005576
GO:0005615
GO:0005739
GO:0005759
GO:0005783
GO:0006085
GO:0006091
GO:0006520
GO:0006550
GO:0006629
GO:0006631
GO:0006635
GO:0006790
GO:0009725
GO:0014070
GO:0015936
GO:0015937
GO:0016453
GO:0016740
GO:0016746
GO:0016747
GO:0019899
GO:0030955
GO:0034736
GO:0042594
GO:0042802
GO:0043226
GO:0046356
GO:0046872
GO:0046952
GO:0048856
GO:0055086
GO:0060612
GO:0070062
GO:0072229
GO:0120225
GO:1901135
GO:1902224
GO:1902860
HMNXSV003041914
Hs2.37.2.S1_3p_at
PH_hs_0000004
PH_hs_0035309
TC11000979.hg
TC11002856.hg
g4557236_3p_s_at
Participates
as a component of
ACAT1 tetramer [mitochondrial matrix] (Homo sapiens)
Inferred To
ACAT1(35-427) [mitochondrial matrix]
(Bos taurus)
ACAT1(35-427) [mitochondrial matrix]
(Caenorhabditis elegans)
ACAT1(35-427) [mitochondrial matrix]
(Canis familiaris)
ACAT1(35-427) [mitochondrial matrix]
(Danio rerio)
ACAT1(35-427) [mitochondrial matrix]
(Dictyostelium discoideum)
ACAT1(35-427) [mitochondrial matrix]
(Gallus gallus)
ACAT1(35-427) [mitochondrial matrix]
(Mus musculus)
ACAT1(35-427) [mitochondrial matrix]
(Plasmodium falciparum)
ACAT1(35-427) [mitochondrial matrix]
(Rattus norvegicus)
ACAT1(35-427) [mitochondrial matrix]
(Sus scrofa)
Acat1 [mitochondrial matrix]
(Drosophila melanogaster)
Cross References
RefSeq
NP_000010.1
Guide to Pharmacology - Targets
2435
OpenTargets
ENSG00000075239
ZINC target
P24752
PRO
P24752
PDB
2F2S
,
2IBY
,
2IBW
,
2IBU
,
2IB9
,
2IB7
,
2IB8
IntEnz
2.3.1.9
GeneCards
P24752
HPA
ENSG00000075239-ACAT1
Ensembl
ENSG00000075239
,
ENST00000299355
,
ENSP00000265838
,
ENSP00000299355
,
ENST00000265838
Pharos - Targets
P24752
Orphanet
15069
HMDB Protein
HMDBP00038
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P19320 VCAM1
1
VCAM1 [plasma membrane]
(R-HSA-197834)
0.527
4
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