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ACAT1(35-427) [mitochondrial matrix]
Stable Identifier
R-HSA-70838
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
acetyl-CoA acetyltransferase, Acetyl-CoA acetyltransferase, mitochondrial, Acetoacetyl-CoA thiolase, ACAT1
Icon
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Aerobic respiration and respiratory electron transport (Homo sapiens)
Citric acid cycle (TCA cycle) (Homo sapiens)
Maturation of TCA enzymes and regulation of TCA cycle (Homo sapiens)
ACAT1 tetramer acetylates IDH2 dimer (Homo sapiens)
ACAT1 tetramer [mitochondrial matrix] (Homo sapiens)
ACAT1(35-427) [mitochondrial matrix] (Homo sapiens)
Metabolism of amino acids and derivatives (Homo sapiens)
Branched-chain amino acid catabolism (Homo sapiens)
alpha-methylacetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Homo sapiens)
ACAT1 tetramer [mitochondrial matrix] (Homo sapiens)
ACAT1(35-427) [mitochondrial matrix] (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Ketone body metabolism (Homo sapiens)
Synthesis of Ketone Bodies (Homo sapiens)
2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Homo sapiens)
ACAT1 tetramer [mitochondrial matrix] (Homo sapiens)
ACAT1(35-427) [mitochondrial matrix] (Homo sapiens)
Utilization of Ketone Bodies (Homo sapiens)
acetoacetyl-CoA + CoA <=> 2 acetyl-CoA (Homo sapiens)
ACAT1 tetramer [mitochondrial matrix] (Homo sapiens)
ACAT1(35-427) [mitochondrial matrix] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Mitochondrial protein degradation (Homo sapiens)
CLPXP binds mitochondrial matrix proteins (Homo sapiens)
CLPXP:substrate protein (mitochondrial matrix) [mitochondrial matrix] (Homo sapiens)
Substrate of CLPXP (mitrochondrial matrix) [mitochondrial matrix] (Homo sapiens)
ACAT1(35-427) [mitochondrial matrix] (Homo sapiens)
Substrate of CLPXP (mitrochondrial matrix) [mitochondrial matrix] (Homo sapiens)
ACAT1(35-427) [mitochondrial matrix] (Homo sapiens)
CLPXP degrades mitochondrial matrix proteins (Homo sapiens)
CLPXP:substrate protein (mitochondrial matrix) [mitochondrial matrix] (Homo sapiens)
Substrate of CLPXP (mitrochondrial matrix) [mitochondrial matrix] (Homo sapiens)
ACAT1(35-427) [mitochondrial matrix] (Homo sapiens)
LONP1 binds mitochondrial matrix proteins (Homo sapiens)
LONP1:substrate protein (mitochondrial matrix) [mitochondrial matrix] (Homo sapiens)
Substrate of LONP1 (mitochondrial matrix) [mitochondrial matrix] (Homo sapiens)
ACAT1(35-427) [mitochondrial matrix] (Homo sapiens)
Substrate of LONP1 (mitochondrial matrix) [mitochondrial matrix] (Homo sapiens)
ACAT1(35-427) [mitochondrial matrix] (Homo sapiens)
LONP1 degrades mitochondrial matrix proteins (Homo sapiens)
LONP1:substrate protein (mitochondrial matrix) [mitochondrial matrix] (Homo sapiens)
Substrate of LONP1 (mitochondrial matrix) [mitochondrial matrix] (Homo sapiens)
ACAT1(35-427) [mitochondrial matrix] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
17371050
Crystallographic and kinetic studies of human mitochondrial acetoacetyl-CoA thiolase: the importance of potassium and chloride ions for its structure and function
Kondo, N
,
Haapalainen, AM
,
Fukao, T
,
Pirilä, PL
,
Wierenga, RK
,
Meriläinen, G
Biochemistry
2007
External Reference Information
External Reference
UniProt:P24752 ACAT1
Gene Names
ACAT1, ACAT, MAT
Chain
transit peptide:1-33, chain:34-427
Reference Genes
BioGPS Gene:38 ACAT1
COSMIC (genes):ACAT1 ACAT1
CTD Gene:38 ACAT1
dbSNP Gene:38 ACAT1
ENSEMBL:ENSG00000075239 ACAT1
HGNC:93 ACAT1
KEGG:hsa:38 ACAT1
Monarch:38 ACAT1
NCBI Gene:38 ACAT1
OMIM:607809 ACAT1
UCSC:P24752 ACAT1
Reference Transcript
RefSeq:NM_000019.3 ACAT1
Other Identifiers
11742973_at
11761280_at
1554947_PM_at
1554947_at
1559239_PM_s_at
1559239_s_at
205412_PM_at
205412_at
3347616
3347617
3347618
3347619
3347620
3347622
3347624
3347626
3347627
3347628
3347629
3347630
3347631
3347632
3347633
3347634
3347635
3347636
3347637
3347638
3347639
3347640
3347641
3347642
3347643
3347644
3347645
3347646
3347647
3347649
3347651
38
39678_at
7943605
A_14_P104456
A_23_P24515
A_24_P203678
A_24_P346967
A_33_P3253975
D10511_at
GE60478
GE746421
GO:0001889
GO:0003824
GO:0003985
GO:0003988
GO:0005739
GO:0005759
GO:0005783
GO:0006085
GO:0006091
GO:0006520
GO:0006550
GO:0006629
GO:0006631
GO:0006635
GO:0006790
GO:0009725
GO:0014070
GO:0015936
GO:0015937
GO:0016453
GO:0016740
GO:0016746
GO:0016747
GO:0019899
GO:0030955
GO:0034736
GO:0042594
GO:0042802
GO:0043226
GO:0046356
GO:0046872
GO:0046952
GO:0048856
GO:0055086
GO:0060612
GO:0070062
GO:0072229
GO:0120225
GO:1901135
GO:1902224
GO:1902860
HMNXSV003041914
Hs2.37.2.S1_3p_at
Hs2.397519.1.S1_3p_s_at
ILMN_1800008
PH_hs_0000004
PH_hs_0035309
TC11000979.hg
TC11002856.hg
g4557236_3p_s_at
Participates
as a member of
Substrate of LONP1 (mitochondrial matrix) [mitochondrial matrix] (Homo sapiens)
Substrate of CLPXP (mitrochondrial matrix) [mitochondrial matrix] (Homo sapiens)
as a component of
ACAT1 tetramer [mitochondrial matrix] (Homo sapiens)
Other forms of this molecule
N158D ACAT1(35-427) [mitochondrial matrix]
G183R ACAT1(35-427) [mitochondrial matrix]
N93S ACAT1(35-427) [mitochondrial matrix]
A333P ACAT1(35-427) [mitochondrial matrix]
A301P ACAT1(35-427) [mitochondrial matrix]
Inferred To
ACAT1 [mitochondrial matrix]
(Canis familiaris)
ACAT1(35-427) [mitochondrial matrix]
(Bos taurus)
ACAT1(35-427) [mitochondrial matrix]
(Caenorhabditis elegans)
ACAT1(35-427) [mitochondrial matrix]
(Danio rerio)
ACAT1(35-427) [mitochondrial matrix]
(Dictyostelium discoideum)
ACAT1(35-427) [mitochondrial matrix]
(Gallus gallus)
ACAT1(35-427) [mitochondrial matrix]
(Mus musculus)
ACAT1(35-427) [mitochondrial matrix]
(Plasmodium falciparum)
ACAT1(35-427) [mitochondrial matrix]
(Rattus norvegicus)
ACAT1(35-427) [mitochondrial matrix]
(Sus scrofa)
ACAT1(35-427) [mitochondrial matrix]
(Xenopus tropicalis)
Acat1 [mitochondrial matrix]
(Drosophila melanogaster)
Cross References
RefSeq
NP_000010.1
Guide to Pharmacology - Targets
2435
OpenTargets
ENSG00000075239
ENSEMBL
ENSG00000075239
,
ENSP00000265838
,
ENSP00000299355
,
ENST00000265838
,
ENST00000299355
ZINC target
P24752
PRO
P24752
GlyGen
P24752
PDB
2IBY
,
2IB8
,
2IBU
,
2IB7
,
2IB9
,
2IBW
,
2F2S
IntEnz
2.3.1.9
HPA
ENSG00000075239-ACAT1
GeneCards
ACAT1
Pharos - Targets
P24752
Orphanet
ACAT1
HMDB Protein
HMDBP00038
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P19320 VCAM1
1
VCAM1 [plasma membrane]
(R-HSA-197834)
0.527
4
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