Mitochondrial ethylglutaconyl-CoA hydratase (AUH) catalyzes the hydrolysis of beta-methylglutaconyl-CoA to yield beta-hydroxy-beta-methylglutaryl-CoA (IJlst et al. 2002; Narisawa et al. 1986). Crystallographic studies have shown the active enzyme to be a hexamer of AUH polypeptides whose aminoterminal 67 residues, a mitochondrial targeting sequence, have been removed ((Kurimoto et al. 2001).
Duran, M, Lehnert, W, IJlst, L, Loupatty, FJ, Ruiter, JP
Duran, M, Wadman, SK, Narisawa, K, Gibson, KM, Nyhan, WL, Sweetman, L
Kurimoto, K, Yokoyama, S, Muto, Y, Nureki, O, Fukai, S
methylglutaconyl-CoA hydratase activity of AUH hexamer [mitochondrial matrix]
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