Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
IVD [mitochondrial matrix]
Stable Identifier
R-HSA-70729
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
isovaleryl-CoA dehydrogenase, apoenzyme, IVD_HUMAN, Isovaleryl-CoA dehydrogenase, mitochondrial precursor
Icon
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of amino acids and derivatives (Homo sapiens)
Branched-chain amino acid catabolism (Homo sapiens)
isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2 (Homo sapiens)
IVD tetramer [mitochondrial matrix] (Homo sapiens)
IVD [mitochondrial matrix] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
9214289
Structure of human isovaleryl-CoA dehydrogenase at 2.6 A resolution: structural basis for substrate specificity,.
Wang, M
,
Paschke, R
,
Tiffany, KA
,
Roberts, DL
,
Kim, JJ
,
Mohsen, AW
,
Vockley, J
Biochemistry
1997
External Reference Information
External Reference
UniProt:P26440 IVD
Gene Names
IVD
Chain
transit peptide:1-32, chain:33-426
Reference Genes
BioGPS Gene:3712 IVD
COSMIC (genes):IVD IVD
CTD Gene:3712 IVD
dbSNP Gene:3712 IVD
ENSEMBL:ENSG00000128928 IVD
HGNC:6186 IVD
KEGG:hsa:3712 IVD
Monarch:3712 IVD
NCBI Gene:3712 IVD
OMIM:607036 IVD
UCSC:P26440 IVD
Reference Transcript
RefSeq:NM_002225.3 IVD
RefSeq:NM_001159508.1 IVD
Other Identifiers
11720642_a_at
11720643_a_at
16799538
203682_PM_s_at
203682_s_at
216958_PM_s_at
216958_s_at
225311_PM_at
225311_at
3589906
3589907
3589908
3589909
3589910
3589911
3589912
3589915
3589916
3589917
3589918
3589919
3589920
3589921
3589922
3589923
3589924
3589925
3589926
3589927
3589928
3589930
3589931
3589932
3589933
3589934
3589935
3589936
3589937
3589938
3589944
3712
37342_s_at
63548_at
78746_at
7982723
81819_at
A_21_P0008622
A_23_P129313
A_23_P129322
A_33_P3269718
GE58276
GE86159
GE86160
GO:0003824
GO:0003995
GO:0005515
GO:0005654
GO:0005739
GO:0005759
GO:0006520
GO:0006552
GO:0006629
GO:0006631
GO:0008470
GO:0009083
GO:0016491
GO:0016627
GO:0016937
GO:0031966
GO:0033539
GO:0042802
GO:0043226
GO:0050660
HMNXSV003014601
HMNXSV003025668
HMNXSV003033658
HMNXSV003042078
Hs.279789.5.A1_3p_at
Hs.279789.5.A1_3p_x_at
Hs.77510.2.S1_3p_a_at
ILMN_1724207
M34192_at
PH_hs_0024828
TC15000284.hg
TC15002158.hg
g6031167_3p_a_at
Participates
as a component of
IVD tetramer [mitochondrial matrix] (Homo sapiens)
Other forms of this molecule
R398Q IVD [mitochondrial matrix]
I379T IVD [mitochondrial matrix]
Y403N IVD [mitochondrial matrix]
D72N IVD [mitochondrial matrix]
V374A IVD [mitochondrial matrix]
R53P IVD [mitochondrial matrix]
G123R IVD [mitochondrial matrix]
R395C IVD [mitochondrial matrix]
M332T IVD [mitochondrial matrix]
A314V IVD [mitochondrial matrix]
L45P IVD [mitochondrial matrix]
R414L IVD [mitochondrial matrix]
T239I IVD [mitochondrial matrix]
R340Q IVD [mitochondrial matrix]
C360R IVD [mitochondrial matrix]
Inferred To
IVD [mitochondrial matrix]
(Bos taurus)
IVD [mitochondrial matrix]
(Caenorhabditis elegans)
IVD [mitochondrial matrix]
(Canis familiaris)
IVD [mitochondrial matrix]
(Danio rerio)
IVD [mitochondrial matrix]
(Dictyostelium discoideum)
IVD [mitochondrial matrix]
(Drosophila melanogaster)
IVD [mitochondrial matrix]
(Gallus gallus)
IVD [mitochondrial matrix]
(Mus musculus)
IVD [mitochondrial matrix]
(Rattus norvegicus)
IVD [mitochondrial matrix]
(Sus scrofa)
IVD [mitochondrial matrix]
(Xenopus tropicalis)
Cross References
OpenTargets
ENSG00000128928
ENSEMBL
ENST00000651168
,
ENST00000650656
,
ENSP00000498731
,
ENSG00000128928
,
ENSP00000499074
IntEnz
1.3.8.4
HPA
ENSG00000128928-IVD
GeneCards
IVD
PRO
P26440
Pharos - Targets
P26440
Orphanet
IVD
HMDB Protein
HMDBP00166
PDB
1IVH
,
8SGR
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q15831 STK11
2
STK11 [cytosol]
(R-HSA-380954)
STK11 [nucleoplasm]
(R-HSA-164119)
0.527
2
UniProt:P43630 KIR3DL2
1
KIR3DL2 [plasma membrane]
(R-HSA-197713)
0.527
2
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text