alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate

Stable Identifier
R-HSA-70471
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
Glucose 6-phosphate is isomerized to form fructose-6-phosphate
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Cytosolic phosphoglucose isomerase catalyzes the reversible interconversion of glucose 6-phosphate and fructose 6-phosphate (Tsuboi et al. 1958; Noltmann 1972; Bloxham and Lardy 1973). The active form of the enzyme is a homodimer (Read et al. 2001). Mutations in the enzyme are associated with hemolytic anemia (Xu and Beutler 1994).

Literature References
PubMed ID Title Journal Year
7989588 The characterization of gene mutations for human glucose phosphate isomerase deficiency associated with chronic hemolytic anemia

Beutler, E, Xu, W

J Clin Invest 1994
13538944 Enzymes of the human erythrocyte. IV. Phosphoglucose isomerase, purification and properties.

Tsuboi, KK, Hudson, PB, Estrada, J

J Biol Chem 1958
  The Enzymes, 3rd ed

Boyer, PD

  1972
11371164 The crystal structure of human phosphoglucose isomerase at 1.6 A resolution: implications for catalytic mechanism, cytokine activity and haemolytic anaemia

Muirhead, H, Read, J, Li, X, Davies, C, Chirgwin, J, Pearce, J

J Mol Biol 2001
  The Enzymes, 3rd ed

Boyer, PD

  1973
Participants
Participates
Event Information
Catalyst Activity

glucose-6-phosphate isomerase activity of GPI dimer [cytosol]

Orthologous Events
Cross References
Rhea
Cite Us!