Reactome | GPI dimer isomerizes G6P

GPI dimer isomerizes G6P

Stable Identifier

R-HSA-70471

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate, Glucose 6-phosphate is isomerized to form fructose-6-phosphate

ReviewStatus

5/5

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Cytosolic phosphoglucose isomerase catalyzes the reversible interconversion of glucose 6-phosphate and fructose 6-phosphate (Tsuboi et al. 1958; Noltmann 1972; Bloxham and Lardy 1973). The active form of the enzyme is a homodimer (Read et al. 2001). Mutations in the enzyme are associated with hemolytic anemia (Xu and Beutler 1994).

Literature References

PubMed ID	Title	Journal	Year
7989588	The characterization of gene mutations for human glucose phosphate isomerase deficiency associated with chronic hemolytic anemia Xu, W, Beutler, E	J Clin Invest	1994
13538944	Enzymes of the human erythrocyte. IV. Phosphoglucose isomerase, purification and properties. Tsuboi, KK, Estrada, J, Hudson, PB	J Biol Chem	1958
	The Enzymes, 3rd ed Boyer, PD		1972
11371164	The crystal structure of human phosphoglucose isomerase at 1.6 A resolution: implications for catalytic mechanism, cytokine activity and haemolytic anaemia Read, J, Pearce, J, Li, X, Muirhead, H, Chirgwin, J, Davies, C	J Mol Biol	2001
	The Enzymes, 3rd ed Boyer, PD		1973