Removal of RNA primer and dissociation of RPA and Dna2

Stable Identifier
R-HSA-69144
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
nucleoplasm
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Removal of RNA primer and dissociation of RPA and Dna2
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The Dna2 endonuclease removes the initiator RNA along with several downstream deoxyribonucleotides. The cleavage of the single-stranded RNA substrate results in the disassembly of RPA and Dna2. The current data for the role of the Dna2 endonuclease has been derived from studies with yeast and Xenopus Dna2.

Literature References
PubMed ID Title Journal Year
11473323 RPA governs endonuclease switching during processing of Okazaki fragments in eukaryotes.

Bae, SH, Bae, KH, Kim, JA, Seo, YS

Nature 2001
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Orthologous Events
Removal of RNA primer and dissociation of RPA and Dna2 (Canis familiaris)
Removal of RNA primer and dissociation of RPA and Dna2 (Danio rerio)
Removal of RNA primer and dissociation of RPA and Dna2 (Drosophila melanogaster)
Removal of RNA primer and dissociation of RPA and Dna2 (Mus musculus)
Removal of RNA primer and dissociation of RPA and Dna2 (Plasmodium falciparum)
Removal of RNA primer and dissociation of RPA and Dna2 (Rattus norvegicus)
Removal of RNA primer and dissociation of RPA and Dna2 (Schizosaccharomyces pombe)
Removal of RNA primer and dissociation of RPA and Dna2 (Sus scrofa)
Removal of RNA primer and dissociation of RPA and Dna2 (Xenopus tropicalis)