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Recruitment of Dna2 endonuclease
Stable Identifier
R-HSA-69142
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
S Phase (Homo sapiens)
Synthesis of DNA (Homo sapiens)
DNA strand elongation (Homo sapiens)
Lagging Strand Synthesis (Homo sapiens)
Processive synthesis on the lagging strand (Homo sapiens)
Removal of the Flap Intermediate (Homo sapiens)
Recruitment of Dna2 endonuclease (Homo sapiens)
DNA Replication (Homo sapiens)
Synthesis of DNA (Homo sapiens)
DNA strand elongation (Homo sapiens)
Lagging Strand Synthesis (Homo sapiens)
Processive synthesis on the lagging strand (Homo sapiens)
Removal of the Flap Intermediate (Homo sapiens)
Recruitment of Dna2 endonuclease (Homo sapiens)
General
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
After RPA binds the long flap, it recruits the Dna2 endonuclease. Dna2 endonuclease removes most of the flap, but the job of complete removal of the flap is then completed by FEN-1.
Literature References
PubMed ID
Title
Journal
Year
11473323
RPA governs endonuclease switching during processing of Okazaki fragments in eukaryotes.
Seo, YS
,
Bae, SH
,
Bae, KH
,
Kim, JA
Nature
2001
Participants
Input
DNA2 [nucleoplasm]
(Homo sapiens)
Processive complex:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm]
(Homo sapiens)
Output
Processive complex:Okazaki fragment:Flap:RPA heterotrimer:dna2 [nucleoplasm]
(Homo sapiens)
Participates
as an event of
Removal of the Flap Intermediate (Homo sapiens)
Orthologous Events
Recruitment of Dna2 endonuclease (Bos taurus)
Recruitment of Dna2 endonuclease (Caenorhabditis elegans)
Recruitment of Dna2 endonuclease (Canis familiaris)
Recruitment of Dna2 endonuclease (Dictyostelium discoideum)
Recruitment of Dna2 endonuclease (Drosophila melanogaster)
Recruitment of Dna2 endonuclease (Mus musculus)
Recruitment of Dna2 endonuclease (Rattus norvegicus)
Recruitment of Dna2 endonuclease (Saccharomyces cerevisiae)
Recruitment of Dna2 endonuclease (Schizosaccharomyces pombe)
Recruitment of Dna2 endonuclease (Sus scrofa)
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