Recruitment of Dna2 endonuclease

Stable Identifier
R-HSA-69142
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
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Recruitment of Dna2 endonuclease
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After RPA binds the long flap, it recruits the Dna2 endonuclease. Dna2 endonuclease removes most of the flap, but the job of complete removal of the flap is then completed by FEN-1.

Literature References
PubMed ID Title Journal Year
11473323 RPA governs endonuclease switching during processing of Okazaki fragments in eukaryotes.

Bae, SH, Bae, KH, Kim, JA, Seo, YS

Nature 2001
Participants
Input
Output
Participant Of
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Orthologous Events
Recruitment of Dna2 endonuclease (Caenorhabditis elegans)
Recruitment of Dna2 endonuclease (Canis familiaris)
Recruitment of Dna2 endonuclease (Danio rerio)
Recruitment of Dna2 endonuclease (Dictyostelium discoideum)
Recruitment of Dna2 endonuclease (Drosophila melanogaster)
Recruitment of Dna2 endonuclease (Mus musculus)
Recruitment of Dna2 endonuclease (Plasmodium falciparum)
Recruitment of Dna2 endonuclease (Rattus norvegicus)
Recruitment of Dna2 endonuclease (Saccharomyces cerevisiae)
Recruitment of Dna2 endonuclease (Schizosaccharomyces pombe)
Recruitment of Dna2 endonuclease (Sus scrofa)
Recruitment of Dna2 endonuclease (Xenopus tropicalis)