Reactome | CDK and DDK associate with the Mcm10:pre-replicative complex

CDK and DDK associate with the Mcm10:pre-replicative complex

Stable Identifier

R-HSA-68918

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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CDK and DDK associate with the Mcm10:pre-replicative complex

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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

At the beginning of this reaction, 1 molecule of 'Mcm10:active pre-replicative complex', 1 molecule of 'DDK', and 1 molecule of 'CDK' are present. At the end of this reaction, 1 molecule of 'CDK:DDK:Mcm10:pre-replicative complex' is present.

This reaction takes place in the 'nucleus'.

Literature References

PubMed ID	Title	Journal	Year
10373557	A novel growth- and cell cycle-regulated protein, ASK, activates human Cdc7-related kinase and is essential for G1/S transition in mammalian cells. Lees, E, Arai, K, Mahony, D, Seghezzi, W, Sato, N, Yamada, M, Kumagai, H, Masai, H	Mol Cell Biol	1999
10523313	Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication. Jiang, W, McDonald, D, Hope, TJ, Hunter, T	EMBO J	1999