Ubiquitinated geminin is degraded by the proteasome

Stable Identifier
R-HSA-68825
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol
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Ubiquitinated geminin is degraded by the proteasome
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At the beginning of this reaction, 1 molecule of 'geminin:ubiquitin complex' is present. At the end of this reaction, 1 molecule of 'ubiquitin' is present.

This reaction takes place in the 'cytosol' and is mediated by the 'endopeptidase activity' of '26S proteasome'.

Literature References
PubMed ID Title Journal Year
11125146 Inhibition of eukaryotic DNA replication by geminin binding to Cdt1.

Wohlschlegel, JA, Dwyer, BT, Dhar, SK, Cvetic, C, Walter, JC, Dutta, A

Science 2000
9635433 Geminin, an inhibitor of DNA replication, is degraded during mitosis.

McGarry, TJ, Kirschner, MW

Cell 1998
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
endopeptidase activity of 26S proteasome [cytosol]
Physical Entity
26S proteasome [cytosol]
Activity
endopeptidase activity (0004175)
Orthologous Events
Ubiquitinated geminin is degraded by the proteasome (Canis familiaris)
Ubiquitinated geminin is degraded by the proteasome (Danio rerio)
Ubiquitinated geminin is degraded by the proteasome (Drosophila melanogaster)
Ubiquitinated geminin is degraded by the proteasome (Mus musculus)
Ubiquitinated geminin is degraded by the proteasome (Rattus norvegicus)
Ubiquitinated geminin is degraded by the proteasome (Sus scrofa)
Ubiquitinated geminin is degraded by the proteasome (Xenopus tropicalis)
Created
Davey, MJ  (2003-06-05)
O'Donnell, M  (2003-06-05)
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