Ubiquitinated geminin is degraded by the proteasome

Stable Identifier
R-HSA-68825
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Ubiquitinated geminin is degraded by the proteasome
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

APC/C-dependent degradation of geminin (GMNN) was first demonstrated in Xenopus (McGarry and Kirschner 1998) and was shown to be proteasome-dependent and sensitive to FBXO5 (Emi1)-mediated inhibition of the APC/C:Cdh1 activity in human cells (Machida and Dutta 2007).

Literature References
PubMed ID Title Journal Year
9635433 Geminin, an inhibitor of DNA replication, is degraded during mitosis.

McGarry, TJ, Kirschner, MW

Cell 1998
17234884 The APC/C inhibitor, Emi1, is essential for prevention of rereplication

Dutta, A, Machida, YJ

Genes Dev 2007
Participants
Input
Output
Participates
as an event of
Catalyst Activity

endopeptidase activity of 26S proteasome [nucleoplasm]

Physical Entity
26S proteasome [nucleoplasm] (Homo sapiens)
Activity
endopeptidase activity (GO:0004175)
Orthologous Events
Ubiquitinated geminin is degraded by the proteasome (Canis familiaris)
Ubiquitinated geminin is degraded by the proteasome (Danio rerio)
Ubiquitinated geminin is degraded by the proteasome (Drosophila melanogaster)
Ubiquitinated geminin is degraded by the proteasome (Mus musculus)
Ubiquitinated geminin is degraded by the proteasome (Rattus norvegicus)
Ubiquitinated geminin is degraded by the proteasome (Sus scrofa)
Reviewed
Kusic-Tisma, J  (2021-11-04)
Created
O'Donnell, M  (2003-06-05)
Davey, MJ  (2003-06-05)
Cite Us!