APC/C-dependent degradation of geminin (GMNN) was first demonstrated in Xenopus (McGarry and Kirschner 1998) and was shown to be proteasome-dependent and sensitive to FBXO5 (Emi1)-mediated inhibition of the APC/C:Cdh1 activity in human cells (Machida and Dutta 2007).
McGarry, TJ, Kirschner, MW
Dutta, A, Machida, YJ
endopeptidase activity of 26S proteasome [nucleoplasm]
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