Ubiquitinated geminin is degraded by the proteasome

Stable Identifier
R-HSA-68825
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
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APC/C-dependent degradation of geminin (GMNN) was first demonstrated in Xenopus (McGarry and Kirschner 1998) and was shown to be proteasome-dependent and sensitive to FBXO5 (Emi1)-mediated inhibition of the APC/C:Cdh1 activity in human cells (Machida and Dutta 2007).

Literature References
PubMed ID Title Journal Year
9635433 Geminin, an inhibitor of DNA replication, is degraded during mitosis.

McGarry, TJ, Kirschner, MW

Cell 1998
17234884 The APC/C inhibitor, Emi1, is essential for prevention of rereplication

Dutta, A, Machida, YJ

Genes Dev 2007
Participants
Participates
Catalyst Activity

endopeptidase activity of 26S proteasome [nucleoplasm]

Orthologous Events
Reviewed
Created
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