Reactome | CDK4:CCND1 [cytosol]

CDK4:CCND1 [cytosol]

Stable Identifier

R-HSA-68331

Type

Complex

Species

Homo sapiens

Compartment

cytosol

Synonyms

Cyclin D1:CDK4 complex

Locations in the PathwayBrowser

Expand all

Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - Mitotic G1 phase and G1/S transition (Homo sapiens)
    - G1 Phase (Homo sapiens)
      - Cyclin D associated events in G1 (Homo sapiens)
        
        Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus (Homo sapiens)
        
        CDK4,CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); CDK4,CDK6:CCND; (CDK4,CDK6:CCND:p-Y88-CDKN1B) [cytosol] (Homo sapiens)
        
        CDK4:CCND [cytosol] (Homo sapiens)
        
        CDK4:CCND1 [cytosol] (Homo sapiens)
    - G1/S Transition (Homo sapiens)
      - Cyclin E associated events during G1/S transition (Homo sapiens)
        
        SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
        
        Activated PTK6 binds CDKN1B (Homo sapiens)
        
        CDKN1B:(CDK4:CCND1,(CDK2:CCNE1)) [cytosol] (Homo sapiens)
        
        CCND1:CDK4,(CCNE1:CDK2) [cytosol] (Homo sapiens)
        
        CDK4:CCND1 [cytosol] (Homo sapiens)
        
        p-Y342-PTK6:CDKN1B:(CDK4:CCND1,(CDK2:CCNE1)) [cytosol] (Homo sapiens)
        
        CDKN1B:(CDK4:CCND1,(CDK2:CCNE1)) [cytosol] (Homo sapiens)
        
        CCND1:CDK4,(CCNE1:CDK2) [cytosol] (Homo sapiens)
        
        CDK4:CCND1 [cytosol] (Homo sapiens)
        
        PTK6 phosphorylates CDKN1B (Homo sapiens)
        
        p-Y342-PTK6:CDKN1B:(CDK4:CCND1,(CDK2:CCNE1)) [cytosol] (Homo sapiens)
        
        CDKN1B:(CDK4:CCND1,(CDK2:CCNE1)) [cytosol] (Homo sapiens)
        
        CCND1:CDK4,(CCNE1:CDK2) [cytosol] (Homo sapiens)
        
        CDK4:CCND1 [cytosol] (Homo sapiens)
        
        p-Y88-CDKN1B:(CDK4:CCND1,(CDK2:CCNE1)) [cytosol] (Homo sapiens)
        
        CCND1:CDK4,(CCNE1:CDK2) [cytosol] (Homo sapiens)
        
        CDK4:CCND1 [cytosol] (Homo sapiens)
  - S Phase (Homo sapiens)
    - Cyclin A:Cdk2-associated events at S phase entry (Homo sapiens)
      - SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
        
        Activated PTK6 binds CDKN1B (Homo sapiens)
        
        CDKN1B:(CDK4:CCND1,(CDK2:CCNE1)) [cytosol] (Homo sapiens)
        
        CCND1:CDK4,(CCNE1:CDK2) [cytosol] (Homo sapiens)
        
        CDK4:CCND1 [cytosol] (Homo sapiens)
        
        p-Y342-PTK6:CDKN1B:(CDK4:CCND1,(CDK2:CCNE1)) [cytosol] (Homo sapiens)
        
        CDKN1B:(CDK4:CCND1,(CDK2:CCNE1)) [cytosol] (Homo sapiens)
        
        CCND1:CDK4,(CCNE1:CDK2) [cytosol] (Homo sapiens)
        
        CDK4:CCND1 [cytosol] (Homo sapiens)
        
        PTK6 phosphorylates CDKN1B (Homo sapiens)
        
        p-Y342-PTK6:CDKN1B:(CDK4:CCND1,(CDK2:CCNE1)) [cytosol] (Homo sapiens)
        
        CDKN1B:(CDK4:CCND1,(CDK2:CCNE1)) [cytosol] (Homo sapiens)
        
        CCND1:CDK4,(CCNE1:CDK2) [cytosol] (Homo sapiens)
        
        CDK4:CCND1 [cytosol] (Homo sapiens)
        
        p-Y88-CDKN1B:(CDK4:CCND1,(CDK2:CCNE1)) [cytosol] (Homo sapiens)
        
        CCND1:CDK4,(CCNE1:CDK2) [cytosol] (Homo sapiens)
        
        CDK4:CCND1 [cytosol] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Signaling by Non-Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by PTK6 (Homo sapiens)
    - PTK6 Regulates Cell Cycle (Homo sapiens)
      - Activated PTK6 binds CDKN1B (Homo sapiens)
        
        CDKN1B:(CDK4:CCND1,(CDK2:CCNE1)) [cytosol] (Homo sapiens)
        
        CCND1:CDK4,(CCNE1:CDK2) [cytosol] (Homo sapiens)
        
        CDK4:CCND1 [cytosol] (Homo sapiens)
        
        p-Y342-PTK6:CDKN1B:(CDK4:CCND1,(CDK2:CCNE1)) [cytosol] (Homo sapiens)
        
        CDKN1B:(CDK4:CCND1,(CDK2:CCNE1)) [cytosol] (Homo sapiens)
        
        CCND1:CDK4,(CCNE1:CDK2) [cytosol] (Homo sapiens)
        
        CDK4:CCND1 [cytosol] (Homo sapiens)
      - PTK6 phosphorylates CDKN1B (Homo sapiens)
        
        p-Y342-PTK6:CDKN1B:(CDK4:CCND1,(CDK2:CCNE1)) [cytosol] (Homo sapiens)
        
        CDKN1B:(CDK4:CCND1,(CDK2:CCNE1)) [cytosol] (Homo sapiens)
        
        CCND1:CDK4,(CCNE1:CDK2) [cytosol] (Homo sapiens)
        
        CDK4:CCND1 [cytosol] (Homo sapiens)
        
        p-Y88-CDKN1B:(CDK4:CCND1,(CDK2:CCNE1)) [cytosol] (Homo sapiens)
        
        CCND1:CDK4,(CCNE1:CDK2) [cytosol] (Homo sapiens)
        
        CDK4:CCND1 [cytosol] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
8114739	Identification of G1 kinase activity for cdk6, a novel cyclin D partner Meyerson, M, Harlow, E	Mol. Cell. Biol.	1994

Participants

components

Participates

as a member of

Inferred To

CDK4:CCND1 [cytosol] (Bos taurus)

CDK4:CCND1 [cytosol] (Canis familiaris)

CDK4:CCND1 [cytosol] (Danio rerio)

CDK4:CCND1 [cytosol] (Drosophila melanogaster)

CDK4:CCND1 [cytosol] (Mus musculus)

CDK4:CCND1 [cytosol] (Rattus norvegicus)

CDK4:CCND1 [cytosol] (Schizosaccharomyces pombe)

CDK4:CCND1 [cytosol] (Sus scrofa)

CDK4:CCND1 [cytosol] (Xenopus tropicalis)