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Fusion of late-endosome derived vesicles at the TGN
Stable Identifier
R-HSA-6814671
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
trans-Golgi network membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Intra-Golgi and retrograde Golgi-to-ER traffic (Homo sapiens)
Retrograde transport at the Trans-Golgi-Network (Homo sapiens)
Fusion of late-endosome derived vesicles at the TGN (Homo sapiens)
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After capture at the trans-Golgi network by SNAREs and tethering factors, late endosome-derived vesicles undergo membrane fusion, delivering cargo and the cis-SNARE complex to the TGN membrane. The details of this fusion event are not fully established (reviewed in Pfeffer, 2011).
Literature References
PubMed ID
Title
Journal
Year
21421921
Entry at the trans-face of the Golgi
Pfeffer, SR
Cold Spring Harb Perspect Biol
2011
Participants
Input
RAB9:GTP:p-RABEPK:VAMP3:STX16:STX10:VTI1A:GARP complex:GCC2 dimer:late-endosome-to-TGN cargo [trans-Golgi network membrane]
(Homo sapiens)
Output
GARP complex [trans-Golgi network membrane]
(Homo sapiens)
GCC2 dimer [cytosol]
(Homo sapiens)
late-endosome-to-TGN cargo [trans-Golgi network membrane]
(Homo sapiens)
RAB9:GDP [cytosol]
(Homo sapiens)
RABEPK [cytosol]
(Homo sapiens)
STX10:STX16:VTI1A:VAMP3 [trans-Golgi network membrane]
(Homo sapiens)
Participates
as an event of
Retrograde transport at the Trans-Golgi-Network (Homo sapiens)
Orthologous Events
Fusion of late-endosome derived vesicles at the TGN (Bos taurus)
Fusion of late-endosome derived vesicles at the TGN (Canis familiaris)
Fusion of late-endosome derived vesicles at the TGN (Gallus gallus)
Fusion of late-endosome derived vesicles at the TGN (Mus musculus)
Fusion of late-endosome derived vesicles at the TGN (Rattus norvegicus)
Fusion of late-endosome derived vesicles at the TGN (Sus scrofa)
Authored
Rothfels, K (2015-11-09)
Reviewed
Gillespie, ME (2016-02-02)
Created
Rothfels, K (2015-11-27)
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