CK2 phosphorylates PDCL

Stable Identifier
R-HSA-6814409
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Casein kinase II complex phosphorylates PhLP
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The casein kinase II (CK2) complex phosphorylates PDCL (PhLP1) at the N-terminal serine residues S18, S19, S20 and S25. The phosphorylation at S20 is the most critical for PDCL-mediated folding of the G-protein beta subunit (Lukov et al. 2005, Lukov et al. 2006).

Literature References
PubMed ID Title Journal Year
15889144 Phosducin-like protein acts as a molecular chaperone for G protein betagamma dimer assembly

Lukov, GL, Hu, T, McLaughlin, JN, Hamm, HE, Willardson, BM

EMBO J. 2005
16717095 Mechanism of assembly of G protein betagamma subunits by protein kinase CK2-phosphorylated phosducin-like protein and the cytosolic chaperonin complex

Lukov, GL, Baker, CM, Ludtke, PJ, Hu, T, Carter, MD, Hackett, RA, Thulin, CD, Willardson, BM

J. Biol. Chem. 2006
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of Casein kinase II [cytosol]
Physical Entity
Activity
Orthologous Events
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