Reactome | ARL1:GTP binds SCOC

ARL1:GTP binds SCOC

Stable Identifier

R-HSA-6814096

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Two hybrid screening with human ARL1 as bait identified SCOC as a novel ARL1:GTP-interacting partner (Van Valkenburgh et al, 2001). SCOC (short coiled coil) shares 26% identity and 51% homology with GOLGA2, binds ARL1:GTPagamma S as assessed by affinity chromatography and shows extensive colocalization wtih beta-COP and ARL1 at the Golgi, however the role of this complex is not known (Van Valkenbrugh et al, 2001). SCOC is also known to play roles in autophagy, as part of a complex with FEZ1 (McKnight et al, 2012; reviewed in Joachim et al, 2012).

Literature References

PubMed ID	Title	Journal	Year
22354037	Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC Tooze, SA, Alemu, EA, Jefferies, HB, Johansen, T, McKnight, NC, Howell, M, Saunders, RE	EMBO J.	2012
11303027	ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins Sharer, JD, Zhu, X, Kahn, RA, Van Valkenburgh, H, Shern, JF	J. Biol. Chem.	2001
22717455	Coiling up with SCOC and WAC: two new regulators of starvation-induced autophagy Tooze, SA, Joachim, J, McKnight, NC, Wirth, M	Autophagy	2012