Reactome | HSD17B14 tetramer oxidises estradiol (EST17b) to estrone (E1)

HSD17B14 tetramer oxidises estradiol (EST17b) to estrone (E1)

Stable Identifier

R-HSA-6810594

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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HSD17B14 tetramer oxidises estradiol (EST17b) to estrone (E1)

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17-beta-hydroxysteroid dehydrogenases are primarily involved in the metabolism of 17-hydroxysteroids and of other substrates such as fatty acids, prostaglandins and xenobiotics. The human DHRS10 gene encodes 17-beta-hydroxysteroid dehydrogenase 14 (HSD17B14) which in tetrameric form can oxidise estradiol (E2) to estrone (E1) in vitro (Lukacik et al. 2007). It shows highest expression in brain, liver and placenta and has been shown to act as a protective factor in breast cancer (Sivik et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
17067289	Structural and biochemical characterization of human orphan DHRS10 reveals a novel cytosolic enzyme with steroid dehydrogenase activity Lukacik, P, Keller, B, Bunkoczi, G, Kavanagh, KL, Kavanagh, K, Lee, WH, Hwa Lee, W, Adamski, J, Oppermann, U	Biochem. J.	2007
22792371	17β-Hydroxysteroid dehydrogenase type 14 is a predictive marker for tamoxifen response in oestrogen receptor positive breast cancer Sivik, T, Gunnarsson, C, Fornander, T, Nordenskjöld, B, Skoog, L, Stål, O, Jansson, A	PLoS ONE	2012