HSD17B14 tetramer oxidises estradiol (E2) to estrone (E1)

Stable Identifier
R-HSA-6810594
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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17-beta-hydroxysteroid dehydrogenases are primarily involved in the metabolism of 17-hydroxysteroids and of other substrates such as fatty acids, prostaglandins and xenobiotics. The human DHRS10 gene encodes 17-beta-hydroxysteroid dehydrogenase 14 (HSD17B14) which in tetrameric form can oxidise estradiol (E2) to estrone (E1) in vitro (Lukacik et al. 2007). It shows highest expression in brain, liver and placenta and has been shown to act as a protective factor in breast cancer (Sivik et al. 2012).

Literature References
PubMed ID Title Journal Year
22792371 17β-Hydroxysteroid dehydrogenase type 14 is a predictive marker for tamoxifen response in oestrogen receptor positive breast cancer

Sivik, T, Gunnarsson, C, Fornander, T, Nordenskjöld, B, Skoog, L, Stål, O, Jansson, A

PLoS ONE 2012
17067289 Structural and biochemical characterization of human orphan DHRS10 reveals a novel cytosolic enzyme with steroid dehydrogenase activity

Lukacik, P, Keller, B, Bunkoczi, G, Kavanagh, KL, Kavanagh, K, Lee, WH, Hwa Lee, W, Adamski, J, Oppermann, U

Biochem. J. 2007
Participants
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Catalyst Activity
Catalyst Activity
Title
estradiol 17-beta-dehydrogenase activity of HSD17B14 tetramer [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
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