Uridine diphosphate glucose pyrophosphatase (NUDT14) is a member of the Nudix hydrolase family, a ubiquitously distributed group of nucleotide pyrophosphatases. NUDT14 hydrolyses UDP-glucose (UDP-Glc) to glucose 1-phosphate (G1P) and UMP. UDP-Glc is a sugar donor in many glycosylation reactions and a cytosolic pyrophosphatase such as NUDT14 could play a role in regulating gluconeogenesis (Yagi et al. 2003).
Yagi, T, Yamamoto, R, Muñoz, FJ, Hong, KS, Akazawa, T, Baroja-Fernández, E, Pozueta-Romero, J
UDP-sugar diphosphatase activity of NUDT14 [cytosol]
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