Reactome | NUDT14 hydrolyses UDP-Glc to G1P and UMP

NUDT14 hydrolyses UDP-Glc to G1P and UMP

Stable Identifier

R-HSA-6810464

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Homo sapiens)
      - Synthesis of substrates in N-glycan biosythesis (Homo sapiens)
        
        Synthesis of dolichyl-phosphate-glucose (Homo sapiens)
        
        NUDT14 hydrolyses UDP-Glc to G1P and UMP (Homo sapiens)

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NUDT14 hydrolyses UDP-Glc to G1P and UMP

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Uridine diphosphate glucose pyrophosphatase (NUDT14) is a member of the Nudix hydrolase family, a ubiquitously distributed group of nucleotide pyrophosphatases. NUDT14 hydrolyses UDP-glucose (UDP-Glc) to glucose 1-phosphate (G1P) and UMP. UDP-Glc is a sugar donor in many glycosylation reactions and a cytosolic pyrophosphatase such as NUDT14 could play a role in regulating gluconeogenesis (Yagi et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
12429023	Cloning, expression and characterization of a mammalian Nudix hydrolase-like enzyme that cleaves the pyrophosphate bond of UDP-glucose Yagi, T, Baroja-Fernández, E, Yamamoto, R, Muñoz, FJ, Akazawa, T, Hong, KS, Pozueta-Romero, J	Biochem. J.	2003