NUDT14 hydrolyses UDP-Glc to G1P and UMP

Stable Identifier
R-HSA-6810464
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Uridine diphosphate glucose pyrophosphatase (NUDT14) is a member of the Nudix hydrolase family, a ubiquitously distributed group of nucleotide pyrophosphatases. NUDT14 hydrolyses UDP-glucose (UDP-Glc) to glucose 1-phosphate (G1P) and UMP. UDP-Glc is a sugar donor in many glycosylation reactions and a cytosolic pyrophosphatase such as NUDT14 could play a role in regulating gluconeogenesis (Yagi et al. 2003).

Literature References
PubMed ID Title Journal Year
12429023 Cloning, expression and characterization of a mammalian Nudix hydrolase-like enzyme that cleaves the pyrophosphate bond of UDP-glucose

Yagi, T, Baroja-Fernández, E, Yamamoto, R, Muñoz, FJ, Akazawa, T, Hong, KS, Pozueta-Romero, J

Biochem. J. 2003
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
UDP-sugar diphosphatase activity of NUDT14 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created