DHCR24 reduces ZYMOL to ZYMSTNL

Stable Identifier
R-HSA-6807064
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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DHCR24 (delta(24)-sterol reductase) associated with the endoplasmic reticulum membranecatalyzes the reduction of ZYMOL (zymosterol) to ZYMSTNL (zymostenol) (Kandutsch & Russell 1960; Mitsche et al. 2015; Waterham et al. 2001).

Literature References
PubMed ID Title Journal Year
11519011 Mutations in the 3beta-hydroxysterol Delta24-reductase gene cause desmosterolosis, an autosomal recessive disorder of cholesterol biosynthesis

Waterham, HR, Koster, J, Romeijn, GJ, Hennekam, RC, Vreken, P, Andersson, HC, FitzPatrick, DR, Kelley, RI

Am J Hum Genet 2001
14404284 Preputial gland tumor sterols. 3. A metabolic pathway from lanosterol to cholesterol

Kandutsch, AA, Russell, AE

J. Biol. Chem. 1960
26114596 Flux analysis of cholesterol biosynthesis in vivo reveals multiple tissue and cell-type specific pathways

Mitsche, MA, McDonald, JG, Hobbs, HH, Cohen, JC

Elife 2015
Participants
Participates
Catalyst Activity

delta24-sterol reductase activity of DHCR24 [endoplasmic reticulum membrane]

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