Reactome | DHCR24 reduces ZYMOL to ZYMSTNL

DHCR24 reduces ZYMOL to ZYMSTNL

Stable Identifier

R-HSA-6807064

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, cytosol

Synonyms

zymosterol + NADPH + H(+) => 5alpha-cholest-8-en-3beta-ol + NADP(+)

ReviewStatus

5/5

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DHCR24 (delta(24)-sterol reductase) associated with the endoplasmic reticulum membranecatalyzes the reduction of ZYMOL (zymosterol) to ZYMSTNL (zymostenol) (Kandutsch & Russell 1960; Mitsche et al. 2015; Waterham et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
14404284	Preputial gland tumor sterols. 3. A metabolic pathway from lanosterol to cholesterol Kandutsch, AA, Russell, AE	J. Biol. Chem.	1960
11519011	Mutations in the 3beta-hydroxysterol Delta24-reductase gene cause desmosterolosis, an autosomal recessive disorder of cholesterol biosynthesis Waterham, HR, Koster, J, Romeijn, GJ, Hennekam, RC, Vreken, P, Andersson, HC, FitzPatrick, DR, Kelley, RI	Am J Hum Genet	2001
26114596	Flux analysis of cholesterol biosynthesis in vivo reveals multiple tissue and cell-type specific pathways Mitsche, MA, McDonald, JG, Hobbs, HH, Cohen, JC	Elife	2015