Reactome | DHCR24 reduces ZYMOL to ZYMSTNL

DHCR24 reduces ZYMOL to ZYMSTNL

Stable Identifier

R-HSA-6807064

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, cytosol

ReviewStatus

5/5

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DHCR24 (delta(24)-sterol reductase) associated with the endoplasmic reticulum membranecatalyzes the reduction of ZYMOL (zymosterol) to ZYMSTNL (zymostenol) (Kandutsch & Russell 1960; Mitsche et al. 2015; Waterham et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
14404284	Preputial gland tumor sterols. 3. A metabolic pathway from lanosterol to cholesterol Russell, AE, Kandutsch, AA	J. Biol. Chem.	1960
11519011	Mutations in the 3beta-hydroxysterol Delta24-reductase gene cause desmosterolosis, an autosomal recessive disorder of cholesterol biosynthesis Vreken, P, Romeijn, GJ, FitzPatrick, DR, Hennekam, RC, Koster, J, Andersson, HC, Kelley, RI, Waterham, HR	Am J Hum Genet	2001
26114596	Flux analysis of cholesterol biosynthesis in vivo reveals multiple tissue and cell-type specific pathways Hobbs, HH, Mitsche, MA, Cohen, JC, McDonald, JG	Elife	2015