The binding of AVEN to apoptotic protease activating factor 1 (APAF1) is thought to interfere with the ability of APAF1 to self-associate during apoptosome assembly (Chau BN et al. 2000). The anti-apoptotic function of AVEN may require the proteolytic removal of the inhibitory N-terminus of AVEN (Melzer IM et al. 2012).
Chau, BN, Cheng, EH, Kerr, DA, Hardwick, JM
© 2021 Reactome