APAF1 binds AVEN

Stable Identifier
R-HSA-6805507
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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APAF1 binds AVEN
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The binding of AVEN to apoptotic protease activating factor 1 (APAF1) is thought to interfere with the ability of APAF1 to self-associate during apoptosome assembly (Chau BN et al. 2000). The anti-apoptotic function of AVEN may require the proteolytic removal of the inhibitory N-terminus of AVEN (Melzer IM et al. 2012).
Literature References
PubMed ID Title Journal Year
10949025 Aven, a novel inhibitor of caspase activation, binds Bcl-xL and Apaf-1

Kerr, DA, Chau, BN, Hardwick, JM, Cheng, EH

Mol. Cell 2000
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Orthologous Events
APAF1 binds AVEN (Bos taurus)
APAF1 binds AVEN (Canis familiaris)
APAF1 binds AVEN (Drosophila melanogaster)
APAF1 binds AVEN (Gallus gallus)
APAF1 binds AVEN (Mus musculus)
APAF1 binds AVEN (Rattus norvegicus)
APAF1 binds AVEN (Sus scrofa)
APAF1 binds AVEN (Xenopus tropicalis)
Authored
Shamovsky, V  (2017-07-26)
Reviewed
Matthews, L  (2018-11-05)
Created
Shamovsky, V  (2015-10-20)
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