p14ARF sequesters MDM2

Stable Identifier
R-HSA-6804996
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
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Binding of p14ARF to MDM2 decreases the half-life of MDM2, likely through promoting MDM2 degradation. Thus, p14ARF inhibits MDM2-mediated ubiquitination and degradation of TP53 (Zhang et al. 1998).

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