Reactome | TP53 forms homotetramers

TP53 forms homotetramers

Stable Identifier

R-HSA-6804762

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Expression and Degradation (Homo sapiens)
        
        Regulation of TP53 Expression (Homo sapiens)
        
        TP53 forms homotetramers (Homo sapiens)

General

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TP53 (p53) functions as a stable homotetramer. The tetramerization domain is located within the C-terminus (Stenger et al. 1994, Waterman et al. 1995, Jeffrey et al. 1995, Wang et al. 1995).

Literature References

PubMed ID	Title	Journal	Year
7878469	Crystal structure of the tetramerization domain of the p53 tumor suppressor at 1.7 angstroms Jeffrey, PD, Gorina, S, Pavletich, NP	Science	1995
7859740	The dihedral symmetry of the p53 tetramerization domain mandates a conformational switch upon DNA binding Waterman, JL, Shenk, JL, Halazonetis, TD	EMBO J.	1995
7891710	Interaction of p53 with its consensus DNA-binding site Wang, Y, Schwedes, JF, Parks, D, Mann, K, Tegtmeyer, P	Mol. Cell. Biol.	1995
7813439	p53 oligomerization and DNA looping are linked with transcriptional activation Stenger, JE, Tegtmeyer, P, Mayr, GA, Reed, M, Wang, Y, Wang, P, Hough, PV, Mastrangelo, IA	EMBO J.	1994