TP53 forms homotetramers

Stable Identifier
Reaction [binding]
Homo sapiens
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TP53 (p53) functions as a stable homotetramer. The tetramerization domain is located within the C-terminus (Stenger et al. 1994, Waterman et al. 1995, Jeffrey et al. 1995, Wang et al. 1995).

Literature References
PubMed ID Title Journal Year
7891710 Interaction of p53 with its consensus DNA-binding site

Wang, Y, Schwedes, JF, Parks, D, Mann, K, Tegtmeyer, P

Mol. Cell. Biol. 1995
7813439 p53 oligomerization and DNA looping are linked with transcriptional activation

Stenger, JE, Tegtmeyer, P, Mayr, GA, Reed, M, Wang, Y, Wang, P, Hough, PV, Mastrangelo, IA

EMBO J. 1994
7859740 The dihedral symmetry of the p53 tetramerization domain mandates a conformational switch upon DNA binding

Waterman, JL, Shenk, JL, Halazonetis, TD

EMBO J. 1995
7878469 Crystal structure of the tetramerization domain of the p53 tumor suppressor at 1.7 angstroms

Jeffrey, PD, Gorina, S, Pavletich, NP

Science 1995
Participant Of
Orthologous Events
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