Reactome | Regulation of TP53 Expression

Regulation of TP53 Expression

Stable Identifier

R-HSA-6804754

Type

Pathway

Species

Homo sapiens

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Expression and Degradation (Homo sapiens)
        
        Regulation of TP53 Expression (Homo sapiens)

General

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Transcription of the TP53 (p53) gene is negatively regulated by the TP53 transcriptional target PRDM1 (BLIMP1), which binds to the promoter region of TP53 and probably induces repressive methylation (Yan et al. 2007).

TP53 functions as a homotetramer (Jeffrey et al. 1995, Waterman et al. 1995).

Literature References

PubMed ID	Title	Journal	Year
7859740	The dihedral symmetry of the p53 tetramerization domain mandates a conformational switch upon DNA binding Waterman, JL, Shenk, JL, Halazonetis, TD	EMBO J.	1995
17264218	BLIMP1 regulates cell growth through repression of p53 transcription Yan, J, Jiang, J, Lim, CA, Wu, Q, Ng, HH, Chin, KC	Proc. Natl. Acad. Sci. U.S.A.	2007
7878469	Crystal structure of the tetramerization domain of the p53 tumor suppressor at 1.7 angstroms Jeffrey, PD, Gorina, S, Pavletich, NP	Science	1995