Reactome | PIAS1 SUMOylates L3MBTL2 with SUMO2

PIAS1 SUMOylates L3MBTL2 with SUMO2

Stable Identifier

R-HSA-6804485

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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PIAS1 and possibly other SUMO E3 ligases SUMOylates L3MBTL2 with SUMO2 at lysine-675 and lysine-700 near the C-terminus (Stielow et al. 2014, Tammsalu et al. 2014). SUMOylation of L3MBTL2 does not appear to affect its chromatin binding activity, however SUMOylation does enhance transcriptional repression of a subset of L3MBTL2-target genes, particularly those with low L3MBTL2 occupancy including pro-inflammatory genes (Stielow et al. 2014). SUMOylated L3MBTL2 appears to increase the level of local ubiquitinated histone H2A (Stielow et al. 2014).

Literature References

PubMed ID	Title	Journal	Year
24782567	Proteome-wide identification of SUMO2 modification sites Tatham, MH, Hay, RT, Tammsalu, T, Ibrahim, AF, Jaffray, EG, Matic, I	Sci Signal	2014
24369422	SUMOylation of the polycomb group protein L3MBTL2 facilitates repression of its target genes Finkernagel, F, Jarek, M, Suske, G, Scharfe, M, Stielow, C, Stielow, B	Nucleic Acids Res.	2014