Reactome | TP53 binds the PRDM1 gene

TP53 binds the PRDM1 gene

Stable Identifier

R-HSA-6804191

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Expression and Degradation (Homo sapiens)
        
        Regulation of TP53 Expression (Homo sapiens)
        
        TP53 binds the PRDM1 gene (Homo sapiens)

General

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TP53 (p53) binds the p53 response element in the third intron of the PRDM1 (BLIMP1) gene (Yan et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
17264218	BLIMP1 regulates cell growth through repression of p53 transcription Yan, J, Jiang, J, Lim, CA, Wu, Q, Ng, HH, Chin, KC	Proc. Natl. Acad. Sci. U.S.A.	2007

Participants

Input

Output

p-S15,S20-TP53:PRDM1 Gene [nucleoplasm] (Homo sapiens)

Participant Of

hasEvent

Regulation of TP53 Expression

Authored

Orlic-Milacic, M (2015-10-14)

Reviewed

Zaccara, S (2016-02-04)

Inga, A (2016-02-04)

Created

Orlic-Milacic, M (2015-10-09)

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