Reactome | SFN dimerizes

SFN dimerizes

Stable Identifier

R-HSA-6803890

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Cycle Genes (Homo sapiens)
        
        TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest (Homo sapiens)
        
        SFN dimerizes (Homo sapiens)

General

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SFN functions as a homodimer (Verdoodt et al. 2006).

Literature References

PubMed ID	Title	Journal	Year
17172876	Characterization of 14-3-3sigma dimerization determinants: requirement of homodimerization for inhibition of cell proliferation Benzinger, A, Holak, TA, Hermeking, H, Verdoodt, B, Popowicz, GM	Cell Cycle	2006