TP53 stimulates SFN expression

Stable Identifier
R-HSA-6803871
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
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TP53 stimulates SFN expression
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Binding of TP53 (p53) to the p53 response element in the promoter region of the SFN (14-3-3 sigma) gene stimulates SFN transcription. SFN expression triggers G2 arrest in response to genotoxic agents by sequestering proteins involved in cell cycle progression in the cytosol (Hermeking et al. 1997, Chan et al. 1999). Formation of the complex of TP53 and ZNF385A (HZF) facilitates TP53-mediated induction of SFN3 (Das et al. 2007).
Literature References
PubMed ID Title Journal Year
17719541 Hzf Determines cell survival upon genotoxic stress by modulating p53 transactivation

Bernstein, A, Aaronson, SA, Kimura, Y, Raj, L, Lee, SW, Das, S, Zhao, B

Cell 2007
10524633 14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage

Vogelstein, B, Chan, TA, Lengauer, C, Kinzler, KW, Hermeking, H

Nature 1999
9659898 14-3-3 sigma is a p53-regulated inhibitor of G2/M progression

Zhang, L, Polyak, K, He, TC, Vogelstein, B, Lengauer, C, Kinzler, KW, Hermeking, H, Thiagalingam, S

Mol. Cell 1997
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
p-S15,S20-TP53 Tetramer:ZNF385A:SFN Gene [nucleoplasm] (Homo sapiens)
Active Unit
p-S15,S20-TP53 Tetramer:ZNF385A [nucleoplasm]
Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Orlic-Milacic, M  (2015-10-07)
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