Binding of TP53 (p53) to the p53 response element in the promoter region of the SFN (14-3-3 sigma) gene stimulates SFN transcription. SFN expression triggers G2 arrest in response to genotoxic agents by sequestering proteins involved in cell cycle progression in the cytosol (Hermeking et al. 1997, Chan et al. 1999). Formation of the complex of TP53 and ZNF385A (HZF) facilitates TP53-mediated induction of SFN3 (Das et al. 2007).
Chan, TA, Hermeking, H, Lengauer, C, Kinzler, KW, Vogelstein, B
Das, S, Raj, L, Zhao, B, Kimura, Y, Bernstein, A, Aaronson, SA, Lee, SW
Hermeking, H, Lengauer, C, Polyak, K, He, TC, Zhang, L, Thiagalingam, S, Kinzler, KW, Vogelstein, B
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