Reactome | TP53 stimulates SFN expression

TP53 stimulates SFN expression

Stable Identifier

R-HSA-6803871

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm, cytosol

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Cycle Genes (Homo sapiens)
        
        TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest (Homo sapiens)
        
        TP53 stimulates SFN expression (Homo sapiens)

General

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Binding of TP53 (p53) to the p53 response element in the promoter region of the SFN (14-3-3 sigma) gene stimulates SFN transcription. SFN expression triggers G2 arrest in response to genotoxic agents by sequestering proteins involved in cell cycle progression in the cytosol (Hermeking et al. 1997, Chan et al. 1999). Formation of the complex of TP53 and ZNF385A (HZF) facilitates TP53-mediated induction of SFN3 (Das et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
10524633	14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage Chan, TA, Hermeking, H, Lengauer, C, Kinzler, KW, Vogelstein, B	Nature	1999
17719541	Hzf Determines cell survival upon genotoxic stress by modulating p53 transactivation Das, S, Raj, L, Zhao, B, Kimura, Y, Bernstein, A, Aaronson, SA, Lee, SW	Cell	2007
9659898	14-3-3 sigma is a p53-regulated inhibitor of G2/M progression Hermeking, H, Lengauer, C, Polyak, K, He, TC, Zhang, L, Thiagalingam, S, Kinzler, KW, Vogelstein, B	Mol. Cell	1997