Reactome | NAAA hydrolyses NAEs to FAs and ethanolamine

NAAA hydrolyses NAEs to FAs and ethanolamine

Stable Identifier

R-HSA-6803753

Type

Reaction [transition]

Species

Homo sapiens

Compartment

lysosomal lumen

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

NAAA hydrolyses NAEs to FAs and ethanolamine

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

N-acylethanolamines (NAEs) are bioactive lipid molecules present in animals and plants. N-acylethanolamine-hydrolyzing acid amidase (NAAA), a heterodimeric lysosomal enzyme is able to hydrolyse NAEs to their respective fatty acids (FAs) and ethanolamine (ETA). The NAEs N-arachidonoylethanolamine (anandamide), N-palmitoylethanolamine, and N-oleoylethanolamine possess cannabimimetic activity, anti-inflammatory and analgesic activities, and anorexic activity, respectively. NAAA can mediate their endogenous levels and shows greatest affinity for N-palmitoylethanolamine (Hong et al. 1999, Tsuboi et al. 2005).

Literature References

PubMed ID	Title	Journal	Year
10610717	Molecular cloning and characterization of a human cDNA and gene encoding a novel acid ceramidase-like protein Park, JH, Schuchman, EH, He, X, Levy, B, Li, CM, Hong, SB, Yoo, OJ, Rhee, HJ	Genomics	1999
15655246	Molecular characterization of N-acylethanolamine-hydrolyzing acid amidase, a novel member of the choloylglycine hydrolase family with structural and functional similarity to acid ceramidase Sun, YX, Okamoto, Y, Tonai, T, Ueda, N, Tsuboi, K, Araki, N	J. Biol. Chem.	2005