N-acylethanolamines (NAEs) are bioactive lipid molecules present in animals and plants. N-acylethanolamine-hydrolyzing acid amidase (NAAA), a heterodimeric lysosomal enzyme is able to hydrolyse NAEs to their respective fatty acids (FAs) and ethanolamine (ETA). The NAEs N-arachidonoylethanolamine (anandamide), N-palmitoylethanolamine, and N-oleoylethanolamine possess cannabimimetic activity, anti-inflammatory and analgesic activities, and anorexic activity, respectively. NAAA can mediate their endogenous levels and shows greatest affinity for N-palmitoylethanolamine (Hong et al. 1999, Tsuboi et al. 2005).
Park, JH, Schuchman, EH, He, X, Levy, B, Li, CM, Hong, SB, Yoo, OJ, Rhee, HJ
Sun, YX, Okamoto, Y, Tonai, T, Ueda, N, Tsuboi, K, Araki, N
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds of NAAA dimer [lysosomal lumen]
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