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RAS mutants:GTP [plasma membrane]
Stable Identifier
R-HSA-6802607
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Oncogenic MAPK signaling (Homo sapiens)
Paradoxical activation of RAF signaling by kinase inactive BRAF (Homo sapiens)
Activated MAP2Ks phosphorylate MAPKs downstream of inactive BRAF mutants (Homo sapiens)
RAS:GTP: inactive p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
mutant RAS:inactive BRAF:p-S338,T491,S494,S729 RAF1 [plasma membrane] (Homo sapiens)
RAS mutants:GTP [plasma membrane] (Homo sapiens)
RAS:GTP:inactive p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
mutant RAS:inactive BRAF:p-S338,T491,S494,S729 RAF1 [plasma membrane] (Homo sapiens)
RAS mutants:GTP [plasma membrane] (Homo sapiens)
Dissociation of paradoxically activated RAS:BRAF complexes (Homo sapiens)
RAS:GTP:inactive p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
mutant RAS:inactive BRAF:p-S338,T491,S494,S729 RAF1 [plasma membrane] (Homo sapiens)
RAS mutants:GTP [plasma membrane] (Homo sapiens)
mutant RAS:inactive BRAF:p-S338,T491,S494,S729 RAF1 [plasma membrane] (Homo sapiens)
RAS mutants:GTP [plasma membrane] (Homo sapiens)
Inactive BRAF mutants bind mutant RAS:GTP (Homo sapiens)
RAS mutants:GTP [plasma membrane] (Homo sapiens)
chemically or genetically inactive BRAF mutants:mutant RAS:GTP [plasma membrane] (Homo sapiens)
RAS mutants:GTP [plasma membrane] (Homo sapiens)
Inactive BRAF mutants:mutant RAS:GTP bind RAF1 (Homo sapiens)
chemically or genetically inactive BRAF mutants:mutant RAS:GTP [plasma membrane] (Homo sapiens)
RAS mutants:GTP [plasma membrane] (Homo sapiens)
mutant RAS:inactive BRAF:RAF1 [plasma membrane] (Homo sapiens)
RAS mutants:GTP [plasma membrane] (Homo sapiens)
RAF is paradoxically phosphorylated downstream of kinase-inactive RAF (Homo sapiens)
mutant RAS:inactive BRAF:RAF1 [plasma membrane] (Homo sapiens)
RAS mutants:GTP [plasma membrane] (Homo sapiens)
mutant RAS:inactive BRAF:p-S338,T491,S494,S729 RAF1 [plasma membrane] (Homo sapiens)
RAS mutants:GTP [plasma membrane] (Homo sapiens)
RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)
RAS:GTP: inactive p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
mutant RAS:inactive BRAF:p-S338,T491,S494,S729 RAF1 [plasma membrane] (Homo sapiens)
RAS mutants:GTP [plasma membrane] (Homo sapiens)
RAS:GTP:inactive p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
mutant RAS:inactive BRAF:p-S338,T491,S494,S729 RAF1 [plasma membrane] (Homo sapiens)
RAS mutants:GTP [plasma membrane] (Homo sapiens)
RAS:GTP:p-RAF complexes paradoxically bind MAP2Ks and MAPKs (Homo sapiens)
RAS:GTP:inactive p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
mutant RAS:inactive BRAF:p-S338,T491,S494,S729 RAF1 [plasma membrane] (Homo sapiens)
RAS mutants:GTP [plasma membrane] (Homo sapiens)
mutant RAS:inactive BRAF:p-S338,T491,S494,S729 RAF1 [plasma membrane] (Homo sapiens)
RAS mutants:GTP [plasma membrane] (Homo sapiens)
Signaling by RAS mutants (Homo sapiens)
Signaling downstream of RAS mutants (Homo sapiens)
Activated MAP2Ks phosphorylate MAPKs downstream of oncogenic RAS (Homo sapiens)
mutant RAS:GTP:p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAS mutants:GTP:p-RAF homo/heterodimer [plasma membrane] (Homo sapiens)
RAS mutants:GTP [plasma membrane] (Homo sapiens)
mutant RAS:GTP:p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAS mutants:GTP:p-RAF homo/heterodimer [plasma membrane] (Homo sapiens)
RAS mutants:GTP [plasma membrane] (Homo sapiens)
Dissociation of oncogenic RAS:RAF complex (Homo sapiens)
RAS mutants:GTP:p-RAF homo/heterodimer [plasma membrane] (Homo sapiens)
RAS mutants:GTP [plasma membrane] (Homo sapiens)
mutant RAS:GTP:p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAS mutants:GTP:p-RAF homo/heterodimer [plasma membrane] (Homo sapiens)
RAS mutants:GTP [plasma membrane] (Homo sapiens)
Homo- or heterodimerization of RAF downstream of mutant RAS (Homo sapiens)
RAS mutants:GTP:RAF [plasma membrane] (Homo sapiens)
RAS mutants:GTP [plasma membrane] (Homo sapiens)
RAS mutants:GTP:RAF homo/heterodimer [plasma membrane] (Homo sapiens)
RAS mutants:GTP [plasma membrane] (Homo sapiens)
Mutant RAS:p-RAF complexes bind MAP2Ks and MAPKs (Homo sapiens)
RAS mutants:GTP:p-RAF homo/heterodimer [plasma membrane] (Homo sapiens)
RAS mutants:GTP [plasma membrane] (Homo sapiens)
mutant RAS:GTP:p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAS mutants:GTP:p-RAF homo/heterodimer [plasma membrane] (Homo sapiens)
RAS mutants:GTP [plasma membrane] (Homo sapiens)
Mutant RAS:p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)
mutant RAS:GTP:p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAS mutants:GTP:p-RAF homo/heterodimer [plasma membrane] (Homo sapiens)
RAS mutants:GTP [plasma membrane] (Homo sapiens)
mutant RAS:GTP:p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAS mutants:GTP:p-RAF homo/heterodimer [plasma membrane] (Homo sapiens)
RAS mutants:GTP [plasma membrane] (Homo sapiens)
RAF is phosphorylated downstream of oncogenic RAS (Homo sapiens)
RAS mutants:GTP:RAF homo/heterodimer [plasma membrane] (Homo sapiens)
RAS mutants:GTP [plasma membrane] (Homo sapiens)
RAS mutants:GTP:p-RAF homo/heterodimer [plasma membrane] (Homo sapiens)
RAS mutants:GTP [plasma membrane] (Homo sapiens)
RAS mutants bind inactive RAF (Homo sapiens)
RAS mutants:GTP [plasma membrane] (Homo sapiens)
RAS mutants:GTP:RAF [plasma membrane] (Homo sapiens)
RAS mutants:GTP [plasma membrane] (Homo sapiens)
Participants
components
GTP [cytosol]
RAS mutants [plasma membrane]
(Homo sapiens)
Participates
as an input of
Inactive BRAF mutants bind mutant RAS:GTP (Homo sapiens)
RAS mutants bind inactive RAF (Homo sapiens)
as a component of
mutant RAS:inactive BRAF:RAF1 [plasma membrane] (Homo sapiens)
chemically or genetically inactive BRAF mutants:mutant RAS:GTP [plasma membrane] (Homo sapiens)
mutant RAS:inactive BRAF:p-S338,T491,S494,S729 RAF1 [plasma membrane] (Homo sapiens)
RAS mutants:GTP:RAF [plasma membrane] (Homo sapiens)
RAS mutants:GTP:RAF homo/heterodimer [plasma membrane] (Homo sapiens)
RAS mutants:GTP:p-RAF homo/heterodimer [plasma membrane] (Homo sapiens)
Disease
Name
Identifier
Synonyms
cancer
DOID:162
malignant tumor, malignant neoplasm, primary cancer
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