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TP53 binds the NLRC4 gene
Stable Identifier
R-HSA-6801355
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
TP53 Regulates Transcription of Cell Death Genes (Homo sapiens)
TP53 Regulates Transcription of Caspase Activators and Caspases (Homo sapiens)
TP53 binds the NLRC4 gene (Homo sapiens)
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TP53 (p53) binds the p53 response element in the promoter of the NLRC4 (Ipaf) gene (Sadasivam et al. 2005).
Literature References
PubMed ID
Title
Journal
Year
15580302
Caspase-1 activator Ipaf is a p53-inducible gene involved in apoptosis
Gupta, S
,
Radha, V
,
Kundu, TK
,
Batta, K
,
Swarup, G
,
Sadasivam, S
Oncogene
2005
Participants
Input
NLRC4 Gene [nucleoplasm]
(Homo sapiens)
p-S15,S20-TP53 Tetramer [nucleoplasm]
(Homo sapiens)
Output
p-S15,S20-TP53:NLRC4 Gene [nucleoplasm]
(Homo sapiens)
Participates
as an event of
TP53 Regulates Transcription of Caspase Activators and Caspases (Homo sapiens)
Authored
Orlic-Milacic, M (2015-10-14)
Reviewed
Zaccara, S (2016-02-04)
Inga, A (2016-02-04)
Created
Orlic-Milacic, M (2015-10-01)
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