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HPN(1-162) [plasma membrane]
Stable Identifier
R-HSA-6800195
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Serine protease hepsin ecNumber3.4.21.106/ecNumber, HEPS_HUMAN, Serine protease hepsin non-catalytic chain
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by MET (Homo sapiens)
MET Receptor Activation (Homo sapiens)
HPN heterodimer cleaves pro-HGF to form HGF dimer (Homo sapiens)
HPN heterodimer [plasma membrane] (Homo sapiens)
HPN(1-162) [plasma membrane] (Homo sapiens)
Signaling by MST1 (Homo sapiens)
HPN heterodimer cleaves pro-MST1 to form MST1 dimer (Homo sapiens)
HPN heterodimer [plasma membrane] (Homo sapiens)
HPN(1-162) [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P05981 HPN
Gene Names
HPN, TMPRSS1
Chain
chain:1-162, chain:163-417
Reference Genes
BioGPS Gene:3249 HPN
COSMIC (genes):HPN HPN
CTD Gene:3249 HPN
dbSNP Gene:3249 HPN
ENSEMBL:ENSG00000105707 HPN
ENSEMBL_homo_sapiens_GENE:ENSG00000105707.15 HPN
HGNC:5155 HPN
KEGG Gene (Homo sapiens):3249 HPN
Monarch:3249 HPN
NCBI Gene:3249 HPN
OMIM:142440 HPN
UCSC:P05981 HPN
Reference Transcript
RefSeq:NM_002151.2 HPN
RefSeq:XM_006723181.3 HPN
RefSeq:XM_005258838.4 HPN
RefSeq:XM_017026731.1 HPN
RefSeq:NM_182983.2 HPN
Other Identifiers
11723084_x_at
11724622_a_at
11732504_a_at
11756669_x_at
16860865
204934_PM_s_at
204934_s_at
205508_PM_at
205508_at
3249
37639_at
3830063
3830064
3830066
3830067
3830068
3830069
3830070
3830071
3830072
3830076
3830078
3830085
3830087
3830089
3830091
3830093
3830095
3830096
3830097
3830098
3830101
3830102
3830103
38516_at
8027728
A_23_P406782
GE59696
GE80801
GO:0003824
GO:0004252
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005635
GO:0005783
GO:0005789
GO:0005886
GO:0005911
GO:0006508
GO:0006575
GO:0008233
GO:0008236
GO:0008360
GO:0009986
GO:0010628
GO:0010719
GO:0010756
GO:0012501
GO:0016020
GO:0016324
GO:0016787
GO:0030154
GO:0030198
GO:0030307
GO:0031965
GO:0034769
GO:0043025
GO:0043066
GO:0043226
GO:0043923
GO:0048856
GO:0050680
GO:0050877
GO:0050910
GO:0051604
GO:0055085
GO:0070008
GO:0070062
GO:0071805
GO:0090103
GO:0097066
GO:0097195
GO:0140096
GO:2000347
GO:2000611
HMNXSV003004361
HMNXSV003010778
HMNXSV003019104
ILMN_1687235
ILMN_1704089
ILMN_2358760
L10338_s_at
PH_hs_0019487
PH_hs_0020038
PH_hs_0035655
TC19000456.hg
X07732_at
g4504480_3p_a_at
g4506804_3p_at
Participates
as a component of
HPN heterodimer [plasma membrane] (Homo sapiens)
Other forms of this molecule
HPN(163-417) [plasma membrane]
Inferred To
Hpn [plasma membrane]
(Mus musculus)
Hpn [plasma membrane]
(Rattus norvegicus)
hpn [plasma membrane]
(Danio rerio)
hpn [plasma membrane]
(Xenopus tropicalis)
HPN [plasma membrane]
(Bos taurus)
HPN [plasma membrane]
(Canis familiaris)
HPN [plasma membrane]
(Sus scrofa)
Cross References
RefSeq
XP_006723244.2
,
NP_892028.1
,
XP_016882220.1
,
NP_002142.1
,
XP_005258895.2
ZINC - World Drugs
HEPS_HUMAN
OpenTargets
ENSG00000105707
ZINC - Substances
HEPS_HUMAN
ZINC target
P05981
PRO
P05981
PDB
5CE1
,
3T2N
,
1Z8G
,
1O5E
,
1P57
,
1O5F
IntEnz
3.4.21.106
HPA
ENSG00000105707-HPN
GeneCards
P05981
Ensembl
ENST00000672452
,
ENSP00000500909
,
ENST00000673426
,
ENST00000262626
,
ENST00000392226
,
ENSG00000105707
,
ENSP00000262626
,
ENSP00000376060
,
ENSP00000500664
Pharos - Targets
P05981
ZINC - Predictions - Purchasable
HEPS_HUMAN
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P11686 SFTPC
9
pro-SFTPC P115L [endoplasmic reticulum membrane]
(R-HSA-5688352)
pro-SFTPC P30L [endoplasmic reticulum membrane]
(R-HSA-5688365)
pro-SFTPC [endoplasmic reticulum membrane]
(R-HSA-5683842)
pro-SFTPC [multivesicular body lumen]
(R-HSA-5685298)
SFTPC [extracellular region]
(R-HSA-5683685)
SFTPC [clathrin-coated endocytic vesicle]
(R-HSA-5686342)
SFTPC [lamellar body]
(R-HSA-5683717)
SFTPC(24-58) [multivesicular body lumen]
(R-HSA-5685899)
SFTPC(59-197) [multivesicular body lumen]
(R-HSA-5685871)
0.556
3
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