TP53 binds PPP1R13L

Stable Identifier
Reaction [binding]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

PPP1R13L encodes the inhibitory member of the ASPP family - iASPP. PPP1R13L binds TP53 (p53) and inhibits its pro-apoptotic transcriptional activity. PPP1R13L cooperates with RAS, adenovirus protein E1A and the human papillomavirus protein E7 in cell transformation (Bergamaschi et al. 2003, Wilson et al. 2014). The C-terminus of PPP1R13L consists of four ankyrin repeats and an SH3 domain that form a p53-binding site. PPP1R13L binds the DNA binding site of TP53 (Robinson et al. 2008). PPP1R13L also interacts with p53 family members TP63 (p63) and TP73 (p73) (Robinson et al. 2008) and inhibits their pro-apoptotic transcriptional activity (Cai et al. 2012).

Literature References
PubMed ID Title Journal Year
12524540 iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human

Kuwabara, PE, Hsieh, JK, Samuels, Y, Zhong, S, Trigiante, G, Lu, X, Campargue, I, O'Connor, DJ, Bergamaschi, D, Tomlinson, ML, O'Neil, NJ, Crook, T

Nat. Genet. 2003
24714389 Inhibitor of apoptosis-stimulating protein of p53 (iASPP) is required for neuronal survival after axonal injury

Wilson, AM, Hauswirth, WW, Boye, SL, Chiodo, VA, Di Polo, A, Brecha, NC

PLoS ONE 2014
22538442 iASPP inhibits p53-independent apoptosis by inhibiting transcriptional activity of p63/p73 on promoters of proapoptotic genes

Qiu, S, Liu, ZJ, Gu, SZ, Gao, X, Cai, Y

Apoptosis 2012
18275817 Biochemical and structural studies of ASPP proteins reveal differential binding to p53, p63, and p73

Lu, X, Robinson, RA, Jones, EY, Siebold, C

Structure 2008
Orthologous Events
Cite Us!