Reactome | GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P

GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P

Stable Identifier

R-HSA-6799604

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P

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Glucosamine-6-phosphate isomerases 1 and 2 (GNPDA1, 2) catalyse the reversible deamination and with an aldo/keto isomerisation of D-glucosamine 6-phosphate (GlcN6P) to D-fructose 6-phosphate (Fru(6)P) and ammonia (NH3). GNDPA1 and 2 function as homohexamers in the cytosol. This reaction could provide a source of energy from catabolic pathways of hexosamines found in glycoproteins and glycolipids (Wolosker et al. 1998, Zhang et al. 2003, Arreola et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
12616532	Cloning and functional characterization of GNPI2, a novel human homolog of glucosamine-6-phosphate isomerase/oscillin Zhang, J, Zhang, W, Zou, D, Chen, G, Wan, T, Li, N, Cao, X	J. Cell. Biochem.	2003
9438414	Molecularly cloned mammalian glucosamine-6-phosphate deaminase localizes to transporting epithelium and lacks oscillin activity Wolosker, H, Kline, D, Bian, Y, Blackshaw, S, Cameron, AM, Fralich, TJ, Schnaar, RL, Snyder, SH	FASEB J.	1998
12965206	Two mammalian glucosamine-6-phosphate deaminases: a structural and genetic study Arreola, R, Valderrama, B, Morante, ML, Horjales, E	FEBS Lett.	2003