GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P

Stable Identifier
R-HSA-6799604
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
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GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P
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Glucosamine-6-phosphate isomerases 1 and 2 (GNPDA1, 2) catalyse the reversible deamination and with an aldo/keto isomerisation of D-glucosamine 6-phosphate (GlcN6P) to D-fructose 6-phosphate (Fru(6)P) and ammonia (NH3). GNDPA1 and 2 function as homohexamers in the cytosol. This reaction could provide a source of energy from catabolic pathways of hexosamines found in glycoproteins and glycolipids (Wolosker et al. 1998, Zhang et al. 2003, Arreola et al. 2003).

Literature References
PubMed ID Title Journal Year
9438414 Molecularly cloned mammalian glucosamine-6-phosphate deaminase localizes to transporting epithelium and lacks oscillin activity

Wolosker, H, Kline, D, Bian, Y, Blackshaw, S, Cameron, AM, Fralich, TJ, Schnaar, RL, Snyder, SH

FASEB J. 1998
12616532 Cloning and functional characterization of GNPI2, a novel human homolog of glucosamine-6-phosphate isomerase/oscillin

Zhang, J, Zhang, W, Zou, D, Chen, G, Wan, T, Li, N, Cao, X

J. Cell. Biochem. 2003
12965206 Two mammalian glucosamine-6-phosphate deaminases: a structural and genetic study

Arreola, R, Valderrama, B, Morante, ML, Horjales, E

FEBS Lett. 2003
Participants
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Output
Participant Of
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Event Information
Go Biological Process
glucosamine catabolic process (0006043)
Catalyst Activity
Catalyst Activity
Title
glucosamine-6-phosphate deaminase activity of GNPDA1,2 hexamers [cytosol]
Physical Entity
GNPDA1,2 hexamers [cytosol]
Activity
glucosamine-6-phosphate deaminase activity (0004342)
Orthologous Events
GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Bos taurus)
GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Caenorhabditis elegans)
GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Canis familiaris)
GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Danio rerio)
GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Dictyostelium discoideum)
GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Drosophila melanogaster)
GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Gallus gallus)
GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Mus musculus)
GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Rattus norvegicus)
GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Sus scrofa)
GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Xenopus tropicalis)
Authored
Jassal, B  (2015-09-25)
Reviewed
D'Eustachio, P  (2016-01-11)
Created
Jassal, B  (2015-09-25)