GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P

Stable Identifier
R-HSA-6799604
Type
Reaction
Species
Homo sapiens
Compartment
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Glucosamine-6-phosphate isomerases 1 and 2 (GNPDA1, 2) catalyse the reversible deamination and with an aldo/keto isomerisation of D-glucosamine 6-phosphate (GlcN6P) to D-fructose 6-phosphate (Fru(6)P) and ammonia (NH3). GNDPA1 and 2 function as homohexamers in the cytosol. This reaction could provide a source of energy from catabolic pathways of hexosamines found in glycoproteins and glycolipids (Wolosker et al. 1998, Zhang et al. 2003, Arreola et al. 2003).

Literature References
PubMed ID Title Journal Year
12616532 Cloning and functional characterization of GNPI2, a novel human homolog of glucosamine-6-phosphate isomerase/oscillin

Chen, G, Wan, T, Li, N, Zou, D, Cao, X, Zhang, W, Zhang, J

J. Cell. Biochem. 2003
9438414 Molecularly cloned mammalian glucosamine-6-phosphate deaminase localizes to transporting epithelium and lacks oscillin activity

Schnaar, RL, Wolosker, H, Kline, D, Cameron, AM, Snyder, SH, Blackshaw, S, Bian, Y, Fralich, TJ

FASEB J. 1998
12965206 Two mammalian glucosamine-6-phosphate deaminases: a structural and genetic study

Horjales, E, Arreola, R, Morante, ML, Valderrama, B

FEBS Lett. 2003
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Participates
Event Information
Catalyst Activity

glucosamine-6-phosphate deaminase activity of GNPDA1,2 hexamers [cytosol]

Orthologous Events
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Rhea
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