Glucosamine-6-phosphate isomerases 1 and 2 (GNPDA1, 2) catalyse the reversible deamination and with an aldo/keto isomerisation of D-glucosamine 6-phosphate (GlcN6P) to D-fructose 6-phosphate (Fru(6)P) and ammonia (NH3). GNDPA1 and 2 function as homohexamers in the cytosol. This reaction could provide a source of energy from catabolic pathways of hexosamines found in glycoproteins and glycolipids (Wolosker et al. 1998, Zhang et al. 2003, Arreola et al. 2003).
Chen, G, Wan, T, Li, N, Zou, D, Cao, X, Zhang, W, Zhang, J
Schnaar, RL, Wolosker, H, Kline, D, Cameron, AM, Snyder, SH, Blackshaw, S, Bian, Y, Fralich, TJ
Horjales, E, Arreola, R, Morante, ML, Valderrama, B
glucosamine-6-phosphate deaminase activity of GNPDA1,2 hexamers [cytosol]
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