BTG2, through its conserved BTG domain, binds catalytic subunits CNOT7 and CNOT8 of the CCR4-NOT complex and promotes mRNA deadenylation activity of the CCR4-NOT (Rouault et al. 1998, Mauxion et al. 2008, Doidge et al. 2012). The interaction with the CCR4-NOT is needed for the antiproliferative activity of BTG2 (Horiuchi et al. 2009, Doidge et al. 2012, Ezzeddine et al. 2012).
Mauxion, F, Faux, C, Séraphin, B
Horiuchi, M, Takeuchi, K, Noda, N, Muroya, N, Suzuki, T, Nakamura, T, Kawamura-Tsuzuku, J, Takahasi, K, Yamamoto, T, Inagaki, F
Rouault, JP, Prévôt, D, Berthet, C, Birot, AM, Billaud, M, Magaud, JP, Corbo, L
Doidge, R, Mittal, S, Aslam, A, Winkler, GS
Ezzeddine, N, Chen, CY, Shyu, AB
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