BTG2, through its conserved BTG domain, binds catalytic subunits CNOT7 and CNOT8 of the CCR4-NOT complex and promotes mRNA deadenylation activity of the CCR4-NOT (Rouault et al. 1998, Mauxion et al. 2008, Doidge et al. 2012). The interaction with the CCR4-NOT is needed for the antiproliferative activity of BTG2 (Horiuchi et al. 2009, Doidge et al. 2012, Ezzeddine et al. 2012).
Aslam, A, Mittal, S, Doidge, R, Winkler, GS
Chen, CY, Ezzeddine, N, Shyu, AB
Horiuchi, M, Inagaki, F, Muroya, N, Takeuchi, K, Kawamura-Tsuzuku, J, Nakamura, T, Suzuki, T, Noda, N, Yamamoto, T, Takahasi, K
Séraphin, B, Mauxion, F, Faux, C
Birot, AM, Corbo, L, Berthet, C, Billaud, M, Rouault, JP, Magaud, JP, Prévôt, D
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