BTG2 binds CCR4-NOT complex

Stable Identifier
Reaction [binding]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
BTG2, through its conserved BTG domain, binds catalytic subunits CNOT7 and CNOT8 of the CCR4-NOT complex and promotes mRNA deadenylation activity of the CCR4-NOT (Rouault et al. 1998, Mauxion et al. 2008, Doidge et al. 2012). The interaction with the CCR4-NOT is needed for the antiproliferative activity of BTG2 (Horiuchi et al. 2009, Doidge et al. 2012, Ezzeddine et al. 2012).
Literature References
PubMed ID Title Journal Year
19276069 Structural basis for the antiproliferative activity of the Tob-hCaf1 complex

Horiuchi, M, Inagaki, F, Muroya, N, Takeuchi, K, Kawamura-Tsuzuku, J, Nakamura, T, Suzuki, T, Noda, N, Yamamoto, T, Takahasi, K

J. Biol. Chem. 2009
18337750 The BTG2 protein is a general activator of mRNA deadenylation

Séraphin, B, Mauxion, F, Faux, C

EMBO J. 2008
9712883 Interaction of BTG1 and p53-regulated BTG2 gene products with mCaf1, the murine homolog of a component of the yeast CCR4 transcriptional regulatory complex

Birot, AM, Corbo, L, Berthet, C, Billaud, M, Rouault, JP, Magaud, JP, Prévôt, D

J. Biol. Chem. 1998
23236473 The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylase subunits of the Ccr4-not complex

Aslam, A, Mittal, S, Doidge, R, Winkler, GS

PLoS ONE 2012
22252318 Evidence providing new insights into TOB-promoted deadenylation and supporting a link between TOB's deadenylation-enhancing and antiproliferative activities

Chen, CY, Ezzeddine, N, Shyu, AB

Mol. Cell. Biol. 2012
Orthologous Events
Cite Us!