BTG2 binds CCR4-NOT complex

Stable Identifier
R-HSA-6798044
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

BTG2, through its conserved BTG domain, binds catalytic subunits CNOT7 and CNOT8 of the CCR4-NOT complex and promotes mRNA deadenylation activity of the CCR4-NOT (Rouault et al. 1998, Mauxion et al. 2008, Doidge et al. 2012). The interaction with the CCR4-NOT is needed for the antiproliferative activity of BTG2 (Horiuchi et al. 2009, Doidge et al. 2012, Ezzeddine et al. 2012).

Literature References
PubMed ID Title Journal Year
23236473 The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylase subunits of the Ccr4-not complex

Aslam, A, Mittal, S, Doidge, R, Winkler, GS

PLoS ONE 2012
22252318 Evidence providing new insights into TOB-promoted deadenylation and supporting a link between TOB's deadenylation-enhancing and antiproliferative activities

Chen, CY, Ezzeddine, N, Shyu, AB

Mol. Cell. Biol. 2012
19276069 Structural basis for the antiproliferative activity of the Tob-hCaf1 complex

Horiuchi, M, Inagaki, F, Muroya, N, Takeuchi, K, Kawamura-Tsuzuku, J, Nakamura, T, Suzuki, T, Noda, N, Yamamoto, T, Takahasi, K

J. Biol. Chem. 2009
18337750 The BTG2 protein is a general activator of mRNA deadenylation

Séraphin, B, Mauxion, F, Faux, C

EMBO J. 2008
9712883 Interaction of BTG1 and p53-regulated BTG2 gene products with mCaf1, the murine homolog of a component of the yeast CCR4 transcriptional regulatory complex

Birot, AM, Corbo, L, Berthet, C, Billaud, M, Rouault, JP, Magaud, JP, Prévôt, D

J. Biol. Chem. 1998
Participants
Participates
Orthologous Events
Authored
Reviewed
Created
Cite Us!