BTG2, through its conserved BTG domain, binds catalytic subunits CNOT7 and CNOT8 of the CCR4-NOT complex and promotes mRNA deadenylation activity of the CCR4-NOT (Rouault et al. 1998, Mauxion et al. 2008, Doidge et al. 2012). The interaction with the CCR4-NOT is needed for the antiproliferative activity of BTG2 (Horiuchi et al. 2009, Doidge et al. 2012, Ezzeddine et al. 2012).
Horiuchi, M, Inagaki, F, Muroya, N, Takeuchi, K, Kawamura-Tsuzuku, J, Nakamura, T, Suzuki, T, Noda, N, Yamamoto, T, Takahasi, K
Séraphin, B, Mauxion, F, Faux, C
Birot, AM, Corbo, L, Berthet, C, Billaud, M, Rouault, JP, Magaud, JP, Prévôt, D
Aslam, A, Mittal, S, Doidge, R, Winkler, GS
Chen, CY, Ezzeddine, N, Shyu, AB
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