Reactome | SGK1 phosphorylates MDM2

SGK1 phosphorylates MDM2

Stable Identifier

R-HSA-6795460

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Expression and Degradation (Homo sapiens)
        
        Regulation of TP53 Degradation (Homo sapiens)
        
        SGK1 phosphorylates MDM2 (Homo sapiens)

General

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SGK1 phosphorylates MDM2 at serine residues S166 and S188, resulting in MDM2 activation (Amato et al. 2009, Lyo et al. 2010). SGK1 may play a more prominent role in MDM2 activation than AKT (Lyo et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
20438709	Phospholipase D stabilizes HDM2 through an mTORC2/SGK1 pathway Lyo, D, Xu, L, Foster, DA	Biochem. Biophys. Res. Commun.	2010
19756449	Sgk1 activates MDM2-dependent p53 degradation and affects cell proliferation, survival, and differentiation Amato, R, D'Antona, L, Porciatti, G, Agosti, V, Menniti, M, Rinaldo, C, Costa, N, Bellacchio, E, Mattarocci, S, Fuiano, G, Soddu, S, Paggi, MG, Lang, F, Perrotti, N	J. Mol. Med.	2009