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PWP2 [nucleoplasm]
Stable Identifier
R-HSA-6790680
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Periodic tryptophan protein 2 homolog, PWP2_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of RNA (Homo sapiens)
rRNA processing (Homo sapiens)
rRNA processing in the nucleus and cytosol (Homo sapiens)
Major pathway of rRNA processing in the nucleolus and cytosol (Homo sapiens)
21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA (Homo sapiens)
18SE pre-rRNA:SSU processome [nucleoplasm] (Homo sapiens)
SSU Processome [nucleoplasm] (Homo sapiens)
UTPB complex [nucleoplasm] (Homo sapiens)
PWP2 [nucleoplasm] (Homo sapiens)
21S pre-rRNA:SSU processome [nucleoplasm] (Homo sapiens)
SSU Processome [nucleoplasm] (Homo sapiens)
UTPB complex [nucleoplasm] (Homo sapiens)
PWP2 [nucleoplasm] (Homo sapiens)
30S pre-rRNA is nucleolytically processed at site 1 to yield 21S pre-rRNA (Homo sapiens)
21S pre-rRNA:SSU processome [nucleoplasm] (Homo sapiens)
SSU Processome [nucleoplasm] (Homo sapiens)
UTPB complex [nucleoplasm] (Homo sapiens)
PWP2 [nucleoplasm] (Homo sapiens)
30S pre-rRNA:SSU processome [nucleoplasm] (Homo sapiens)
SSU Processome [nucleoplasm] (Homo sapiens)
UTPB complex [nucleoplasm] (Homo sapiens)
PWP2 [nucleoplasm] (Homo sapiens)
45S pre-rRNA is nucleolytically processed at site 2 (site 2b) to yield 30S pre-rRNA and 32S pre-rRNA (Homo sapiens)
30S pre-rRNA:SSU processome [nucleoplasm] (Homo sapiens)
SSU Processome [nucleoplasm] (Homo sapiens)
UTPB complex [nucleoplasm] (Homo sapiens)
PWP2 [nucleoplasm] (Homo sapiens)
45S pre-rRNA:SSU processome [nucleoplasm] (Homo sapiens)
SSU Processome [nucleoplasm] (Homo sapiens)
UTPB complex [nucleoplasm] (Homo sapiens)
PWP2 [nucleoplasm] (Homo sapiens)
47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6) to yield 45S pre-rRNA (Homo sapiens)
45S pre-rRNA:SSU processome [nucleoplasm] (Homo sapiens)
SSU Processome [nucleoplasm] (Homo sapiens)
UTPB complex [nucleoplasm] (Homo sapiens)
PWP2 [nucleoplasm] (Homo sapiens)
47S pre-rRNA:SSU processome [nucleoplasm] (Homo sapiens)
SSU Processome [nucleoplasm] (Homo sapiens)
UTPB complex [nucleoplasm] (Homo sapiens)
PWP2 [nucleoplasm] (Homo sapiens)
rRNA modification in the nucleus and cytosol (Homo sapiens)
EMG1 of the SSU processome methylates pseudouridine-1248 of 18S rRNA yielding N(1)-methylpseudouridine-1248 (Homo sapiens)
SSU Processome [nucleoplasm] (Homo sapiens)
UTPB complex [nucleoplasm] (Homo sapiens)
PWP2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q15269 PWP2
Gene Names
PWP2, PWP2H
Chain
chain:1-919
Reference Genes
BioGPS Gene:5822 PWP2
COSMIC (genes):PWP2 PWP2
CTD Gene:5822 PWP2
dbSNP Gene:5822 PWP2
ENSEMBL:ENSG00000241945 PWP2
HGNC:9711 PWP2
Monarch:5822 PWP2
NCBI Gene:5822 PWP2
OMIM:601475 PWP2
UCSC:Q15269 PWP2
Reference Transcript
RefSeq:NM_005049.2 PWP2
RefSeq:XM_011508903.2 PWP2
RefSeq:XM_006723910.1 PWP2
Other Identifiers
11757394_a_at
16923491
209336_PM_at
209336_at
37555_at
3923499
3923501
3923502
3923503
3923504
3923505
3923506
3923507
3923508
3923509
3923510
3923511
3923512
3923513
3923514
3923515
3923516
3923517
3923518
3923519
3923520
3923521
3923522
3923523
3923524
3923525
3923526
3923527
3923528
3923530
3923531
3923532
3923533
5822
8069003
A_14_P128136
A_23_P102925
GE60173
GO:0000028
GO:0000462
GO:0003723
GO:0005515
GO:0005634
GO:0005654
GO:0005730
GO:0031981
GO:0032040
GO:0034388
GO:0042254
GO:0042274
GO:0043226
GO:0065003
HMNXSV003048897
ILMN_1698950
PH_hs_0026237
PH_hs_0033703
TC21001065.hg
U56085_at
g1737065_3p_at
Participates
as a component of
UTPB complex [nucleoplasm] (Homo sapiens)
Inferred To
Pwp2 [nucleoplasm]
(Mus musculus)
Pwp2 [nucleoplasm]
(Rattus norvegicus)
pwp2 [nucleoplasm]
(Dictyostelium discoideum)
Dmel\CG12325 [nucleoplasm]
(Drosophila melanogaster)
PWP2 [nucleoplasm]
(Bos taurus)
PWP2 [nucleoplasm]
(Caenorhabditis elegans)
PWP2 [nucleoplasm]
(Canis familiaris)
PWP2 [nucleoplasm]
(Gallus gallus)
PWP2 [nucleoplasm]
(Plasmodium falciparum)
PWP2 [nucleoplasm]
(Saccharomyces cerevisiae)
PWP2 [nucleoplasm]
(Schizosaccharomyces pombe)
PWP2 [nucleoplasm]
(Sus scrofa)
Cross References
ENSEMBL
ENST00000291576
,
ENSP00000291576
OpenTargets
ENSG00000241945
HPA
ENSG00000241945-PWP2
PRO
Q15269
Pharos - Targets
Q15269
GlyGen
Q15269
PDB
7MQA
,
7MQ9
,
7MQ8
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y5J1 UTP18
1
UTP18 [nucleoplasm]
(R-HSA-6790645)
0.564
2
UniProt:Q8IWZ6 BBS7
1
BBS7 [cytosol]
(R-HSA-5617632)
0.527
2
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