IL4 binds IL4R:JAK2

Stable Identifier
R-HSA-6786101
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, extracellular region, plasma membrane
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IL4 binds IL4R:JAK2
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The first step in the formation of both types of IL4 receptor is the binding of Interleukin-4 (IL4) with Interleukin-4 receptor subunit alpha (IL4R) , which has Janus kinase 2 (JAK2) constitutively associated (Hoffman et al. 1995, Shen et al. 1996, Hage et al. 1999).

Literature References
PubMed ID Title Journal Year
8797861 Global and local determinants for the kinetics of interleukin-4/interleukin-4 receptor alpha chain interaction. A biosensor study employing recombinant interleukin-4-binding protein

Shen, BJ, Hage, T, Sebald, W

Eur. J. Biochem. 1996
7795521 Direct evidence of a heterotrimeric complex of human interleukin-4 with its receptors

Hoffman, RC, Castner, BJ, Gerhart, M, Gibson, MG, Rasmussen, BD, March, CJ, Weatherbee, J, Tsang, M, Gustchina, A, Schalk-Hihi, C

Protein Sci. 1995
10219247 Crystal structure of the interleukin-4/receptor alpha chain complex reveals a mosaic binding interface

Hage, T, Sebald, W, Reinemer, P

Cell 1999
Participants
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Output
Participant Of
hasEvent
Orthologous Events
IL4 binds IL4R:JAK2 (Canis familiaris)
IL4 binds IL4R:JAK2 (Mus musculus)
IL4 binds IL4R:JAK2 (Rattus norvegicus)
Authored
Jupe, S  (2015-07-01)
Reviewed
Leibovich, SJ  (2016-09-02)
Created
Jupe, S  (2015-07-03)
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