Reactome | IL4 binds IL4R:JAK2

IL4 binds IL4R:JAK2

Stable Identifier

R-HSA-6786101

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, extracellular region, plasma membrane

ReviewStatus

5/5

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The first step in the formation of both types of IL4 receptor is the binding of Interleukin-4 (IL4) with Interleukin-4 receptor subunit alpha (IL4R) , which has Janus kinase 2 (JAK2) constitutively associated (Hoffman et al. 1995, Shen et al. 1996, Hage et al. 1999).

Literature References

PubMed ID	Title	Journal	Year
7795521	Direct evidence of a heterotrimeric complex of human interleukin-4 with its receptors Hoffman, RC, Castner, BJ, Gerhart, M, Gibson, MG, Rasmussen, BD, March, CJ, Weatherbee, J, Tsang, M, Gustchina, A, Schalk-Hihi, C	Protein Sci.	1995
8797861	Global and local determinants for the kinetics of interleukin-4/interleukin-4 receptor alpha chain interaction. A biosensor study employing recombinant interleukin-4-binding protein Shen, BJ, Hage, T, Sebald, W	Eur. J. Biochem.	1996
10219247	Crystal structure of the interleukin-4/receptor alpha chain complex reveals a mosaic binding interface Hage, T, Sebald, W, Reinemer, P	Cell	1999