Reactome | IL4 [extracellular region]

IL4 [extracellular region]

Stable Identifier

R-HSA-447110

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Interleukin-4, IL4_HUMAN

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P05112 IL4

Gene Names

IL4

Chain

signal peptide:1-24, chain:25-153

Reference Genes

BioGPS Gene:3565 IL4

COSMIC (genes):IL4 IL4

CTD Gene:3565 IL4

dbSNP Gene:3565 IL4

ENSEMBL:ENSG00000113520 IL4

ENSEMBL_homo_sapiens_GENE:ENSG00000113520.11 IL4

HGNC:6014 IL4

KEGG Gene (Homo sapiens):3565 IL4

Monarch:3565 IL4

NCBI Gene:3565 IL4

OMIM:147780 IL4

UCSC:P05112 IL4

Reference Transcript

Other Identifiers

11735020_a_at

1574_s_at

16989103

207538_PM_at

207538_at

207539_PM_s_at

207539_s_at

2828702

2828703

2828704

2828705

2828706

2828707

2828708

33981_at

3565

8107977

A_14_P110135

A_23_P213706

GE80659

GO:0000122

GO:0001774

GO:0002227

GO:0002230

GO:0002376

GO:0002674

GO:0002677

GO:0005125

GO:0005126

GO:0005136

GO:0005515

GO:0005576

GO:0005615

GO:0006091

GO:0006310

GO:0006351

GO:0006355

GO:0006629

GO:0006914

GO:0006954

GO:0006955

GO:0007155

GO:0007165

GO:0008083

GO:0008203

GO:0008284

GO:0010628

GO:0010633

GO:0012501

GO:0016192

GO:0016239

GO:0023052

GO:0030154

GO:0030183

GO:0030335

GO:0030890

GO:0031296

GO:0032720

GO:0032733

GO:0032736

GO:0035771

GO:0036211

GO:0042092

GO:0042102

GO:0042110

GO:0042113

GO:0042116

GO:0042325

GO:0042531

GO:0042976

GO:0043011

GO:0043031

GO:0043066

GO:0043306

GO:0045064

GO:0045191

GO:0045348

GO:0045582

GO:0045671

GO:0045892

GO:0045893

GO:0045944

GO:0048018

GO:0048260

GO:0048295

GO:0048304

GO:0048856

GO:0048870

GO:0050728

GO:0050776

GO:0055086

GO:0071677

GO:0097028

GO:0097192

GO:0098542

GO:0098772

GO:0120162

GO:0150076

GO:0150079

GO:1900223

GO:1901135

GO:1901741

GO:1901857

GO:1903660

GO:1903845

GO:2000320

GO:2000352

GO:2000424

GO:2000553

GO:2001171

GO:2001237

HMNXSV003048238

ILMN_1669174

ILMN_2389080

M13982_at

PH_hs_0004225

TC05000641.hg

X81851_s_at

g4504668_3p_a_at

Participates

as a member of

IL4, IL13 [extracellular region] (Homo sapiens)

as an input of

IL4 binds IL4R:JAK2 (Homo sapiens)

as a component of

Inferred To

IL4 [extracellular region] (Bos taurus)

IL4 [extracellular region] (Canis familiaris)

IL4 [extracellular region] (Gallus gallus)

IL4 [extracellular region] (Sus scrofa)

Il4 [extracellular region] (Mus musculus)

Il4 [extracellular region] (Rattus norvegicus)

Cross References

RefSeq

NP_758858.1, NP_000580.1

OpenTargets

ENSG00000113520

GeneCards

P05112

HPA

ENSG00000113520-IL4

Ensembl

ENSP00000325190, ENST00000231449, ENST00000350025, ENSG00000113520, ENSP00000231449

PRO

P05112

Pharos - Targets

P05112

PDB

3BPL, 1HIJ, 3BPN, 1ITM, 1ITL, 1RCB, 1HZI, 2B8X, 8CH7, 1BCN, 1HIK, 2B8U, 8CGF, 4YDY, 2CYK, 1IAR, 2B91, 6OEL, 1BBN, 5FHX, 2INT, 2B8Y, 8A4F, 1CYL, 2B90, 3QB7, 1ITI, 2D48, 2B8Z

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P24394 IL4R	2	IL4R [plasma membrane] (R-HSA-449670) p-Y-IL4R [plasma membrane] (R-HSA-6786087)	0.811	7
UniProt:P31785 IL2RG	4	IL2RG [plasma membrane] (R-HSA-449139) p-Y-IL2RG [plasma membrane] (R-HSA-6786103) p-Y-IL2RG [cytosol] (R-HSA-9009721) IL2RG [endosome] (R-HSA-8983165)	0.667	3
UniProt:P78552 IL13RA1	2	IL13RA1 [plasma membrane] (R-HSA-449671) p-Y-IL13RA1 [plasma membrane] (R-HSA-6786750)	0.611	3

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