Reactome | IL4 [extracellular region]

IL4 [extracellular region]

Stable Identifier

R-HSA-447110

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Interleukin-4, IL4_HUMAN

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External Reference Information

External Reference

UniProt:P05112 IL4

Gene Names

IL4

Chain

signal peptide:1-24, chain:25-153

Reference Genes

BioGPS Gene:3565 IL4

COSMIC (genes):IL4 IL4

CTD Gene:3565 IL4

dbSNP Gene:3565 IL4

ENSEMBL:ENSG00000113520 IL4

HGNC:6014 IL4

KEGG Gene (Homo sapiens):3565 IL4

Monarch:3565 IL4

NCBI Gene:3565 IL4

OMIM:147780 IL4

UCSC:P05112 IL4

Reference Transcript

Other Identifiers

0002100347

11735020_a_at

1574_s_at

16989103

1BBN

1BCN

1CYL

1HIJ

1HIK

1HZI

1IAR

1ILL

1ITE

1ITI

1ITL

1ITM

1RCB

207538_at

207539_s_at

2828701

2828702

2828703

2828704

2828705

2828706

2828707

2828708

2B8U

2B8X

2B8Y

2B8Z

2B90

2B91

2CYK

2D48

2INT

33981_at

3565

3BPL

3BPN

3QB7

4YDY

5FHX

72995

8107977

A_14_P110135

A_23_P213706

AAA59149

AAA59150

AAH66277

AAH67514

AAH70123

AAK71324

AB102862

ADD60204

AF395008

BAD89396

BC066277

BC067514

BC070123

CAA29925

CAA57444

CCDS4158

CCDS4159

CH471062

D4HNR6

EAW62322

EAW62323

ENSG00000113520

ENSP00000231449

ENSP00000325190

ENST00000231449

ENST00000231449.6

ENST00000350025

ENST00000350025.2

EntrezGene:3565

EntrezGene:IL4

FJ807883

g4504668_3p_a_at

GE80659

GO:0002376

GO:0003674

GO:0005125

GO:0005126

GO:0005136

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0006091

GO:0006259

GO:0006464

GO:0006629

GO:0006810

GO:0006914

GO:0006950

GO:0006955

GO:0007155

GO:0007165

GO:0008083

GO:0008150

GO:0008203

GO:0008219

GO:0008283

GO:0009056

GO:0009058

GO:0010628

GO:0010633

GO:0016192

GO:0016239

GO:0019221

GO:0030154

GO:0030183

GO:0030890

GO:0032736

GO:0034641

GO:0035745

GO:0040011

GO:0042092

GO:0042102

GO:0042110

GO:0042113

GO:0042325

GO:0042531

GO:0042536

GO:0042592

GO:0042976

GO:0043011

GO:0043066

GO:0044281

GO:0045189

GO:0045191

GO:0045348

GO:0045582

GO:0045671

GO:0045892

GO:0045893

GO:0045944

GO:0048260

GO:0048295

GO:0048304

GO:0048856

GO:0048870

GO:0050776

GO:0097028

GO:0120162

GO:0150076

GO:0150079

GO:1900223

GO:1901857

GO:1903660

GO:2000352

GO:2001171

HGNC:6014

HPA072995

IL4

IL4-201

IL4-202

ILMN_1669174

ILMN_2389080

IPR001325

IPR002354

IPR009079

IPR018096

M13982

M13982_at

M23442

MIM:147780

NM_000589

NM_172348

NP_000580

NP_758858

PF00727

PH_hs_0004225

PR00431

Q5FC01

SM00190

TC05000641.hg

U3LVN1

UPI0000004D10

UPI000002B781

X06750

X81851

X81851_s_at

Participant Of

hasMember

IL4, IL13 [extracellular region]

input

IL4 binds IL4R:JAK2

hasComponent

Inferred To

IL4 [extracellular region] (Bos taurus)

IL4 [extracellular region] (Canis familiaris)

IL4 [extracellular region] (Sus scrofa)

Il4 [extracellular region] (Mus musculus)

Il4 [extracellular region] (Rattus norvegicus)

Ghost homologue of IL4 [extracellular region] (Danio rerio)

Ghost homologue of IL4 [extracellular region] (Xenopus tropicalis)

Cross References

RefSeq

NP_758858.1, NP_000580.1

OpenTargets

ENSG00000113520

GeneCards

P05112

HPA

ENSG00000113520-IL4

Ensembl

ENST00000231449, ENSP00000231449, ENST00000350025, ENSP00000325190, ENSG00000113520

PRO

P05112

PDB

1HIK, 2B8Z, 1ILL, 1HIJ, 1BBN, 3BPN, 1RCB, 2B90, 3QB7, 1ITM, 2B91, 2D48, 2CYK, 1IAR, 1BCN, 4YDY, 1ITI, 2B8U, 2INT, 1HZI, 1ITL, 2B8X, 1CYL, 5FHX, 3BPL, 6OEL, 1ITE, 2B8Y

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P24394 IL4R	2	IL4R [plasma membrane] (R-HSA-449670) p-Y-IL4R [plasma membrane] (R-HSA-6786087)	0.811	7
UniProt:P31785 IL2RG	4	p-Y-IL2RG [cytosol] (R-HSA-9009721) IL2RG [endosome] (R-HSA-8983165) p-Y-IL2RG [plasma membrane] (R-HSA-6786103) IL2RG [plasma membrane] (R-HSA-449139)	0.667	3
UniProt:P78552 IL13RA1	2	p-Y-IL13RA1 [plasma membrane] (R-HSA-6786750) IL13RA1 [plasma membrane] (R-HSA-449671)	0.611	3

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