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IL4
Stable Identifier
R-HSA-447110
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Interleukin-4, IL4_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-1 family signaling (Homo sapiens)
Interleukin-18 signaling (Homo sapiens)
Expression of IL18, ALOX5 (Homo sapiens)
IL4, IL13 [extracellular region] (Homo sapiens)
IL4 [extracellular region] (Homo sapiens)
Interleukin-10 signaling (Homo sapiens)
Expression of PTGS2 (Homo sapiens)
IL4, IL13 [extracellular region] (Homo sapiens)
IL4 [extracellular region] (Homo sapiens)
Interleukin-4 and 13 signaling (Homo sapiens)
Expression of CD36 (Homo sapiens)
IL4, IL13 [extracellular region] (Homo sapiens)
IL4 [extracellular region] (Homo sapiens)
Expression of HMOX1 (Homo sapiens)
IL4, IL13 [extracellular region] (Homo sapiens)
IL4 [extracellular region] (Homo sapiens)
Expression of HSPA8, ALOX15 (Homo sapiens)
IL4, IL13 [extracellular region] (Homo sapiens)
IL4 [extracellular region] (Homo sapiens)
Expression of IL18, ALOX5 (Homo sapiens)
IL4, IL13 [extracellular region] (Homo sapiens)
IL4 [extracellular region] (Homo sapiens)
Expression of IL4, IL13-upregulated extracellular proteins (Homo sapiens)
IL4, IL13 [extracellular region] (Homo sapiens)
IL4 [extracellular region] (Homo sapiens)
Expression of IL4,IL13-downregulated extracellular genes (Homo sapiens)
IL4, IL13 [extracellular region] (Homo sapiens)
IL4 [extracellular region] (Homo sapiens)
Expression of MAOA (Homo sapiens)
IL4, IL13 [extracellular region] (Homo sapiens)
IL4 [extracellular region] (Homo sapiens)
Expression of PTGS2 (Homo sapiens)
IL4, IL13 [extracellular region] (Homo sapiens)
IL4 [extracellular region] (Homo sapiens)
IL4 binds IL4R:JAK2 (Homo sapiens)
IL4 [extracellular region] (Homo sapiens)
IL4:IL4R:JAK2 [plasma membrane] (Homo sapiens)
IL4 [extracellular region] (Homo sapiens)
IL4:IL4R:JAK2 binds IL13RA1:TYK2 (Homo sapiens)
IL4:IL4R:JAK2 [plasma membrane] (Homo sapiens)
IL4 [extracellular region] (Homo sapiens)
IL4:IL4R:JAK2:IL13RA1:TYK2 [plasma membrane] (Homo sapiens)
IL4:IL4R:JAK2 [plasma membrane] (Homo sapiens)
IL4 [extracellular region] (Homo sapiens)
IL4:IL4R:JAK2 binds IL2RG:JAK3 (Homo sapiens)
IL4:IL4R:JAK2 [plasma membrane] (Homo sapiens)
IL4 [extracellular region] (Homo sapiens)
IL4:IL4R:JAK2:IL2RG:JAK3 [plasma membrane] (Homo sapiens)
IL4:IL4R:JAK2 [plasma membrane] (Homo sapiens)
IL4 [extracellular region] (Homo sapiens)
IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated (Homo sapiens)
IL4:IL4R:JAK2:IL2RG:JAK3:JAK1 [plasma membrane] (Homo sapiens)
IL4:IL4R:JAK2:IL2RG:JAK3 [plasma membrane] (Homo sapiens)
IL4:IL4R:JAK2 [plasma membrane] (Homo sapiens)
IL4 [extracellular region] (Homo sapiens)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Homo sapiens)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3 [plasma membrane] (Homo sapiens)
IL4:p-Y-IL4R:JAK2 [plasma membrane] (Homo sapiens)
IL4 [extracellular region] (Homo sapiens)
JAK1 binds IL4R in IL4-bound IL4R1 (Homo sapiens)
IL4:IL4R:JAK2:IL2RG:JAK3 [plasma membrane] (Homo sapiens)
IL4:IL4R:JAK2 [plasma membrane] (Homo sapiens)
IL4 [extracellular region] (Homo sapiens)
IL4:IL4R:JAK2:IL2RG:JAK3:JAK1 [plasma membrane] (Homo sapiens)
IL4:IL4R:JAK2:IL2RG:JAK3 [plasma membrane] (Homo sapiens)
IL4:IL4R:JAK2 [plasma membrane] (Homo sapiens)
IL4 [extracellular region] (Homo sapiens)
JAK1 phosphorylates STAT3,STAT6 (Homo sapiens)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1:STAT3,STAT6 [plasma membrane] (Homo sapiens)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Homo sapiens)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3 [plasma membrane] (Homo sapiens)
IL4:p-Y-IL4R:JAK2 [plasma membrane] (Homo sapiens)
IL4 [extracellular region] (Homo sapiens)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1:p-Y705-STAT3,p-Y641-STAT6 [plasma membrane] (Homo sapiens)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Homo sapiens)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3 [plasma membrane] (Homo sapiens)
IL4:p-Y-IL4R:JAK2 [plasma membrane] (Homo sapiens)
IL4 [extracellular region] (Homo sapiens)
SOCS5,(SOCS1) bind IL4RA (Homo sapiens)
IL4:IL4R:JAK2:IL13RA1:TYK2 [plasma membrane] (Homo sapiens)
IL4:IL4R:JAK2 [plasma membrane] (Homo sapiens)
IL4 [extracellular region] (Homo sapiens)
IL4:IL4R:JAK2:IL13RA:TYK2:SOCS5,(SOCS1) [plasma membrane] (Homo sapiens)
IL4:IL4R:JAK2:IL13RA1:TYK2 [plasma membrane] (Homo sapiens)
IL4:IL4R:JAK2 [plasma membrane] (Homo sapiens)
IL4 [extracellular region] (Homo sapiens)
STAT3,STAT6 bind p-Y-IL4R (Homo sapiens)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Homo sapiens)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3 [plasma membrane] (Homo sapiens)
IL4:p-Y-IL4R:JAK2 [plasma membrane] (Homo sapiens)
IL4 [extracellular region] (Homo sapiens)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1:STAT3,STAT6 [plasma membrane] (Homo sapiens)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Homo sapiens)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3 [plasma membrane] (Homo sapiens)
IL4:p-Y-IL4R:JAK2 [plasma membrane] (Homo sapiens)
IL4 [extracellular region] (Homo sapiens)
p-Y705-STAT3,p-Y641-STAT6 dissociate (Homo sapiens)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Homo sapiens)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3 [plasma membrane] (Homo sapiens)
IL4:p-Y-IL4R:JAK2 [plasma membrane] (Homo sapiens)
IL4 [extracellular region] (Homo sapiens)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1:p-Y705-STAT3,p-Y641-STAT6 [plasma membrane] (Homo sapiens)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Homo sapiens)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3 [plasma membrane] (Homo sapiens)
IL4:p-Y-IL4R:JAK2 [plasma membrane] (Homo sapiens)
IL4 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P05112 IL4
Gene Names
IL4
Chain
signal peptide:1-24, chain:25-153
Reference Genes
BioGPS Gene:3565 IL4
COSMIC (genes):IL4 IL4
CTD Gene:3565 IL4
dbSNP Gene:3565 IL4
ENSEMBL:ENSG00000113520 IL4
HGNC:6014 IL4
KEGG Gene (Homo sapiens):hsa:3565 IL4
Monarch:3565 IL4
NCBI Gene:3565 IL4
OMIM:147780 IL4
UCSC:P05112 IL4
Reference Transcript
RefSeq:NM_000589.3 IL4
RefSeq:NM_172348.2 IL4
Other Identifiers
0002100347
11735020_a_at
1574_s_at
16989103
1BBN
1BCN
1CYL
1HIJ
1HIK
1HZI
1IAR
1ILL
1ITE
1ITI
1ITL
1ITM
1RCB
207538_at
207539_s_at
2828702
2828703
2828704
2828705
2828706
2828707
2828708
2B8U
2B8X
2B8Y
2B8Z
2B90
2B91
2CYK
2D48
2INT
33981_at
3565
3BPL
3BPN
3QB7
4YDY
5FHX
8107977
A_14_P110135
A_23_P213706
CCDS4158
CCDS4159
D4HNR6
ENSG00000113520
ENSP00000231449
ENSP00000325190
ENST00000231449
ENST00000350025
EntrezGene:3565
g4504668_3p_a_at
GE80659
GO:0001774
GO:0001934
GO:0002227
GO:0002230
GO:0002296
GO:0002639
GO:0002674
GO:0002677
GO:0005125
GO:0005126
GO:0005136
GO:0005515
GO:0005576
GO:0005615
GO:0006935
GO:0006955
GO:0006968
GO:0007565
GO:0007584
GO:0008083
GO:0008203
GO:0008284
GO:0009897
GO:0010155
GO:0010469
GO:0010633
GO:0014070
GO:0030183
GO:0030890
GO:0031296
GO:0032733
GO:0032736
GO:0034097
GO:0035745
GO:0042092
GO:0042102
GO:0042104
GO:0042113
GO:0042325
GO:0042493
GO:0042531
GO:0042832
GO:0043011
GO:0043031
GO:0043066
GO:0043306
GO:0045019
GO:0045064
GO:0045080
GO:0045189
GO:0045191
GO:0045348
GO:0045471
GO:0045582
GO:0045671
GO:0045892
GO:0045893
GO:0045944
GO:0048295
GO:0048304
GO:0050727
GO:0050731
GO:0050776
GO:0050868
GO:0050871
GO:0051091
GO:0060041
GO:0070351
GO:0071288
GO:0071677
GO:0097028
GO:0097192
GO:1901741
GO:1903428
GO:1903660
GO:2000320
GO:2000352
GO:2000424
GO:2001237
HGNC:6014
IL4
IL4-201
IL4-202
ILMN_1669174
ILMN_2389080
M13982_at
MIM:147780
NM_000589
NM_172348
NP_000580
NP_758858
PF00727
PH_hs_0004225
PR00431
Q5FC01
SM00190
TC05000641.hg
U3LVN1
uc003kxk.3
uc003kxl.3
UPI0000004D10
UPI000002B781
X81851_s_at
Participant Of
input
IL4 binds IL4R:JAK2
hasMember
IL4, IL13 [extracellular region]
hasComponent
IL4:IL4R:JAK2 [plasma membrane]
IL4:p-Y-IL4R:JAK2 [plasma membrane]
Inferred To
IL4 [extracellular region] (Bos taurus)
IL4 [extracellular region] (Canis familiaris)
IL4 [extracellular region] (Mus musculus)
IL4 [extracellular region] (Rattus norvegicus)
IL4 [extracellular region] (Sus scrofa)
Ghost homologue of IL4 [extracellular region] (Gallus gallus)
Ghost homologue of IL4 [extracellular region] (Taeniopygia guttata)
Cross References
RefSeq
NP_758858.1
,
NP_000580.1
GeneCards
P05112
DOCK Blaster
2B90
,
3BPL
,
3BPN
,
2B8X
,
2B8Y
,
2B8Z
,
3QB7
,
4YDY
,
1IAR
,
2D48
,
2INT
,
2B8U
,
5FHX
,
2B91
,
1HIK
,
1HIJ
,
1HZI
,
1RCB
PRO
P05112
PDB
4YDY
,
1ILL
,
5FHX
,
1ITE
,
1ITI
,
1ITL
,
2B8Y
,
2B8X
,
2B8U
,
1RCB
,
1ITM
,
1CYL
,
2CYK
,
1BCN
,
2B91
,
1BBN
,
2B90
,
2B8Z
,
3QB7
,
1IAR
,
3BPN
,
1HZI
,
3BPL
,
1HIK
,
2INT
,
1HIJ
,
2D48
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P24394 IL4R
2
p-Y-IL4R [plasma membrane]
(R-HSA-6786087)
IL4R [plasma membrane]
(R-HSA-449670)
0.811
7
UniProt:P31785 IL2RG
4
p-Y-IL2RG [plasma membrane]
(R-HSA-6786103)
IL2RG [plasma membrane]
(R-HSA-449139)
p-Y-IL2RG [cytosol]
(R-HSA-9009721)
IL2RG [endosome]
(R-HSA-8983165)
0.667
3
UniProt:P78552 IL13RA1
2
p-Y-IL13RA1 [plasma membrane]
(R-HSA-6786750)
IL13RA1 [plasma membrane]
(R-HSA-449671)
0.611
3
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