MEMO1 binds RHOA:GTP:DIAPH1

Stable Identifier
R-HSA-6785648
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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MEMO1, in complex with phosphorylated ERBB2 heterodimers, associates with the complex of activated RHOA and formin family member DIAPH1. MEMO1 maintains the plasma membrane association of the RHOA:GTP:DIAPH1 complex (Zaoui et al. 2008) and modulates RHOA:GTP:DIAPH1-regulated actin and microtubule dynamics and the consequent cell motility/migration downstream of ERBB2 (Marone et al. 2004, Zaoui et al. 2010).

Literature References
PubMed ID Title Journal Year
18955552 Memo-RhoA-mDia1 signaling controls microtubules, the actin network, and adhesion site formation in migrating cells

Zaoui, K, Honoré, S, Isnardon, D, Braguer, D, Badache, A

J. Cell Biol. 2008
20937854 ErbB2 receptor controls microtubule capture by recruiting ACF7 to the plasma membrane of migrating cells

Zaoui, K, Benseddik, K, Daou, P, Salaün, D, Badache, A

Proc. Natl. Acad. Sci. U.S.A. 2010
15156151 Memo mediates ErbB2-driven cell motility

Marone, R, Hess, D, Dankort, D, Muller, WJ, Hynes, NE, Badache, A

Nat. Cell Biol. 2004
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