Reactome | MEMO1 binds RHOA:GTP:DIAPH1

MEMO1 binds RHOA:GTP:DIAPH1

Stable Identifier

R-HSA-6785648

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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MEMO1, in complex with phosphorylated ERBB2 heterodimers, associates with the complex of activated RHOA and formin family member DIAPH1. MEMO1 maintains the plasma membrane association of the RHOA:GTP:DIAPH1 complex (Zaoui et al. 2008) and modulates RHOA:GTP:DIAPH1-regulated actin and microtubule dynamics and the consequent cell motility/migration downstream of ERBB2 (Marone et al. 2004, Zaoui et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
20937854	ErbB2 receptor controls microtubule capture by recruiting ACF7 to the plasma membrane of migrating cells Zaoui, K, Benseddik, K, Salaün, D, Daou, P, Badache, A	Proc. Natl. Acad. Sci. U.S.A.	2010
18955552	Memo-RhoA-mDia1 signaling controls microtubules, the actin network, and adhesion site formation in migrating cells Zaoui, K, Isnardon, D, Honoré, S, Braguer, D, Badache, A	J. Cell Biol.	2008
15156151	Memo mediates ErbB2-driven cell motility Dankort, D, Hess, D, Muller, WJ, Marone, R, Hynes, NE, Badache, A	Nat. Cell Biol.	2004