ERBB2 Regulates Cell Motility

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R-HSA-6785631
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Pathway
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Homo sapiens
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Activated ERBB2 heterodimers regulate cell motility through association with MEMO1. MEMO1 retains activated RHOA GTPase and its associated protein DIAPH1 at the plasma membrane, thus linking ERBB2 activation with the microtubule and actin dynamics downstream of the RHOA:GTP:DIAPH1 complex (Marone et al. 2004, Qiu et al. 2008, Zaoui et al. 2008, Zaoui et al. 2010).

Literature References
PubMed ID Title Journal Year
18045866 Memo is homologous to nonheme iron dioxygenases and binds an ErbB2-derived phosphopeptide in its vestigial active site

Qiu, C, Lienhard, S, Hynes, NE, Badache, A, Leahy, DJ

J. Biol. Chem. 2008
20937854 ErbB2 receptor controls microtubule capture by recruiting ACF7 to the plasma membrane of migrating cells

Zaoui, K, Benseddik, K, Daou, P, Salaün, D, Badache, A

Proc. Natl. Acad. Sci. U.S.A. 2010
18955552 Memo-RhoA-mDia1 signaling controls microtubules, the actin network, and adhesion site formation in migrating cells

Zaoui, K, Honoré, S, Isnardon, D, Braguer, D, Badache, A

J. Cell Biol. 2008
15156151 Memo mediates ErbB2-driven cell motility

Marone, R, Hess, D, Dankort, D, Muller, WJ, Hynes, NE, Badache, A

Nat. Cell Biol. 2004
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