Activated ERBB2 heterodimers regulate cell motility through association with MEMO1. MEMO1 retains activated RHOA GTPase and its associated protein DIAPH1 at the plasma membrane, thus linking ERBB2 activation with the microtubule and actin dynamics downstream of the RHOA:GTP:DIAPH1 complex (Marone et al. 2004, Qiu et al. 2008, Zaoui et al. 2008, Zaoui et al. 2010).
Zaoui, K, Benseddik, K, Salaün, D, Daou, P, Badache, A
Leahy, DJ, Hynes, NE, Qiu, C, Lienhard, S, Badache, A
Zaoui, K, Isnardon, D, Honoré, S, Braguer, D, Badache, A
Dankort, D, Hess, D, Muller, WJ, Marone, R, Hynes, NE, Badache, A
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