EKC complex threonylcarbamoylates A37 of tRNAs

Stable Identifier
R-HSA-6784494
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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EKC complex threonylcarbamoylates A37 of tRNAs
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As inferred from the yeast homologs (EKC complex, KEOPS complex, BUD32:CGI121:KAE1:PCC1), the EKC complex (LAGE3:OSGEP:TP53RK:TPRKB) transfers a threonylcarbamoyl group from L-threonylcarbamoyladenylate to adenosine-37 of tRNAs, yielding threonylcarbamoyladenosine-37.
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Output
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Event Information
Go Biological Process
tRNA modification (0006400)
Catalyst Activity

N(6)-L-threonylcarbamoyladenine synthase activity of EKC complex [nucleoplasm]

Physical Entity
EKC complex [nucleoplasm] (Homo sapiens)
Activity
N(6)-L-threonylcarbamoyladenine synthase activity (GO:0061711)
Inferred From
EKC/KEOPS complex threonylcarbamoylates adenosine-37 of tRNAs (Saccharomyces cerevisiae)
Authored
May, B  (2015-06-20)
Reviewed
Levinger, L  (2015-08-11)
Motorin, Y  (2015-08-25)
Jarrous, N  (2015-10-24)
Created
May, B  (2015-06-20)
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