KEOPS (EKC) complex threonylcarbamoylates A37 of tRNAs

Stable Identifier
R-HSA-6784494
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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KEOPS (EKC) complex threonylcarbamoylates A37 of tRNAs
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The KEOPS (EKC) complex (LAGE3:OSGEP:TP53RK:TPRKB:C14orf142) transfers a threonylcarbamoyl group from L-threonylcarbamoyladenylate to adenosine-37 of tRNAs, yielding threonylcarbamoyladenosine-37 (Arrondel et al. 2019, and inferred from yeast homologs BUD32:CGI121:KAE1:PCC1:GON7).
Literature References
PubMed ID Title Journal Year
31481669 Defects in t6A tRNA modification due to GON7 and YRDC mutations lead to Galloway-Mowat syndrome

Arrondel, C, Missoury, S, Snoek, R, Patat, J, Menara, G, Collinet, B, Liger, D, Durand, D, Gribouval, O, Boyer, O, Buscara, L, Martin, G, Machuca, E, Nevo, F, Lescop, E, Braun, DA, Boschat, AC, Sanquer, S, Guerrera, IC, Revy, P, Parisot, M, Masson, C, Boddaert, N, Charbit, M, Decramer, S, Novo, R, Macher, MA, Ranchin, B, Bacchetta, J, Laurent, A, Collardeau-Frachon, S, van Eerde, AM, Hildebrandt, F, Magen, D, Antignac, C, Van Tilbeurgh, H, Mollet, G

Nat Commun 2019
Participants
Input
Output
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as an event of
Event Information
Go Biological Process
tRNA modification (0006400)
Catalyst Activity

tRNA N(6)-L-threonylcarbamoyladenine synthase activity of KEOPS complex [nucleoplasm]

Physical Entity
KEOPS complex [nucleoplasm] (Homo sapiens)
Activity
tRNA N(6)-L-threonylcarbamoyladenine synthase activity (GO:0061711)
Inferred From
KEOPS (EKC) complex threonylcarbamoylates adenosine-37 of tRNAs (Saccharomyces cerevisiae)
Authored
May, B  (2015-06-20)
Reviewed
Levinger, L  (2015-08-11)
Motorin, Y  (2015-08-25)
Jarrous, N  (2015-10-24)
Created
May, B  (2015-06-20)
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