EKC/KEOPS complex threonylcarbamoylates adenosine-37 of tRNAs

Stable Identifier
R-SCE-6784469
Type
Reaction [transition]
Species
Saccharomyces cerevisiae
Compartment
General
SVG |   | PPTX  | SBGN
EKC/KEOPS complex threonylcarbamoylates adenosine-37 of tRNAs

The highly conserved EKC complex (BUD32:CGI121:KAE1:PCC1) transfers a threonylcarbamoyl group from L-threonylcarbamoyladenylate to adenosine-37 of tRNAs, yielding threonylcarbamoyladenosine-37 (Srinivasan et al. 2011, Perrochia et al. 2013).

Literature References
PubMed ID Title Journal Year
21183954 The highly conserved KEOPS/EKC complex is essential for a universal tRNA modification, t6A

Srinivasan, M, Mehta, P, Yu, Y, Prugar, E, Koonin, EV, Karzai, AW, Sternglanz, R

EMBO J. 2011
23945934 Functional assignment of KEOPS/EKC complex subunits in the biosynthesis of the universal t6A tRNA modification

Perrochia, L, Guetta, D, Hecker, A, Forterre, P, Basta, T

Nucleic Acids Res. 2013
Participants
Event Information
Go Biological Process
Catalyst Activity
Catalyst Activity
Title
N(6)-L-threonylcarbamoyladenine synthase activity of EKC complex [nucleoplasm]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created