EKC/KEOPS complex threonylcarbamoylates adenosine-37 of tRNAs

Stable Identifier
R-SCE-6784469
Type
Reaction [transition]
Species
Saccharomyces cerevisiae
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
EKC/KEOPS complex threonylcarbamoylates adenosine-37 of tRNAs
The highly conserved EKC complex (BUD32:CGI121:KAE1:PCC1) transfers a threonylcarbamoyl group from L-threonylcarbamoyladenylate to adenosine-37 of tRNAs, yielding threonylcarbamoyladenosine-37 (Srinivasan et al. 2011, Perrochia et al. 2013).
Literature References
PubMed ID Title Journal Year
23945934 Functional assignment of KEOPS/EKC complex subunits in the biosynthesis of the universal t6A tRNA modification

Basta, T, Perrochia, L, Hecker, A, Forterre, P, Guetta, D

Nucleic Acids Res. 2013
21183954 The highly conserved KEOPS/EKC complex is essential for a universal tRNA modification, t6A

Prugar, E, Koonin, EV, Srinivasan, M, Yu, Y, Sternglanz, R, Mehta, P, Karzai, AW

EMBO J. 2011
Participants
Input
Output
Event Information
Go Biological Process
tRNA modification (0006400)
Catalyst Activity

N(6)-L-threonylcarbamoyladenine synthase activity of EKC complex [nucleoplasm]

Physical Entity
EKC complex [nucleoplasm] (Saccharomyces cerevisiae)
Activity
N(6)-L-threonylcarbamoyladenine synthase activity (GO:0061711)
Orthologous Events
EKC complex threonylcarbamoylates A37 of tRNAs (Homo sapiens)
Authored
May, B  (2015-06-20)
Reviewed
Motorin, Y  (2015-08-25)
Jarrous, N  (2015-10-24)
Created
May, B  (2015-06-20)
Cite Us!