HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate

Stable Identifier
R-HSA-6784423
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
4-hydroxy-2-oxoglutarate => glyoxylate + pyruvate
ReviewStatus
5/5
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HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate
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Mitochondrial HOGA1 aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate. The mature protein lacks a 25-residue mitochondrial targeting sequence and forms a homotetramer (Riedel et al. 2011).
Literature References
PubMed ID Title Journal Year
21998747 Structural and biochemical studies of human 4-hydroxy-2-oxoglutarate aldolase: implications for hydroxyproline metabolism in primary hyperoxaluria

Knight, J, Holmes, RP, Hantgan, RR, Johnson, LC, Riedel, TJ, Lowther, WT

PLoS ONE 2011
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
glyoxylate metabolic process (0046487)
Catalyst Activity

(R,S)-4-hydroxy-2-oxoglutarate aldolase activity of HOGA1 tetramer [mitochondrial matrix]

Physical Entity
HOGA1 tetramer [mitochondrial matrix] (Homo sapiens)
Activity
(R,S)-4-hydroxy-2-oxoglutarate aldolase activity (GO:0008700)
Orthologous Events
HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate (Bos taurus)
HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate (Canis familiaris)
HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate (Danio rerio)
HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate (Gallus gallus)
HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate (Mus musculus)
HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate (Rattus norvegicus)
HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate (Sus scrofa)
HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate (Xenopus tropicalis)
Cross References
RHEA
Rhea
Authored
D'Eustachio, P  (2015-06-19)
Reviewed
Jassal, B  (2016-12-23)
Created
D'Eustachio, P  (2015-06-19)
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