Mitochondrial HOGA1 aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate. The biochemical details of the enzyme are inferred from the properties of its well-studied rat homologue (Maitra & Dekker 1964). The mature protein lacks a 25-residue mitochondrial targeting sequence and forms a homotetramer (Riedel et al. 2011).
Knight, J, Holmes, RP, Hantgan, RR, Johnson, LC, Riedel, TJ, Lowther, WT
Maitra, U, Dekker, EE
4-hydroxy-2-oxoglutarate aldolase activity of HOGA1 tetramer [mitochondrial matrix]
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