Reactome | HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate

HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate

Stable Identifier

R-HSA-6784423

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

(4R)-4-hydroxy-2-oxoglutarate => glyoxylate + pyruvate

ReviewStatus

5/5

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HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate

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Mitochondrial HOGA1 aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate. The mature protein lacks a 25-residue mitochondrial targeting sequence and forms a homotetramer (Riedel et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
21998747	Structural and biochemical studies of human 4-hydroxy-2-oxoglutarate aldolase: implications for hydroxyproline metabolism in primary hyperoxaluria Riedel, TJ, Johnson, LC, Knight, J, Hantgan, RR, Holmes, RP, Lowther, WT	PLoS ONE	2011