Reactome | PolyUb-RCE1 [cytosol]

PolyUb-RCE1 [cytosol]

Stable Identifier

R-HSA-6782807

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

RCE1, CAAX prenyl protease 2, FACE2_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Deubiquitination (Homo sapiens)
    - Ub-specific processing proteases (Homo sapiens)
      - USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Homo sapiens)
        
        USP17:PolyUb-RCE1, PolyUb-CDC25A, PolyUb-DDX58, PolyUb-IFIH1 [cytosol] (Homo sapiens)
        
        PolyUb-RCE1, PolyUb-CDC25A, PolyUb-DDX58, PolyUb-IFIH1 [cytosol] (Homo sapiens)
        
        PolyUb-RCE1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9Y256 RCE1

Gene Names

RCE1, FACE2, RCE1A, RCE1B

Chain

initiator methionine:, chain:2-329

Reference Genes

BioGPS Gene:9986 RCE1

COSMIC (genes):RCE1 RCE1

CTD Gene:9986 RCE1

dbSNP Gene:9986 RCE1

ENSEMBL:ENSG00000173653 RCE1

ENSEMBL_homo_sapiens_GENE:ENSG00000173653.8 RCE1

HGNC:13721 RCE1

KEGG Gene (Homo sapiens):9986 RCE1

Monarch:9986 RCE1

NCBI Gene:9986 RCE1

OMIM:605385 RCE1

UCSC:Q9Y256 RCE1

Reference Transcript

Other Identifiers

11726760_s_at

11726761_x_at

16727596

205333_PM_s_at

205333_s_at

3336556

3336558

3336560

3336562

3336565

3336566

3336567

3336569

3336571

3336572

3336573

40938_at

7941732

9986

A_14_P134834

GE58356

GO:0000165

GO:0003824

GO:0004175

GO:0004197

GO:0004222

GO:0005783

GO:0005789

GO:0005829

GO:0005886

GO:0006508

GO:0008233

GO:0008238

GO:0016020

GO:0016485

GO:0016787

GO:0018342

GO:0023052

GO:0036211

GO:0043226

GO:0051604

GO:0071586

GO:0080120

GO:0140096

HMNXSV003037779

ILMN_1685002

ILMN_2337492

TC11003464.hg

g4826975_3p_at

Participates

as a member of

PolyUb-RCE1, PolyUb-CDC25A, PolyUb-DDX58, PolyUb-IFIH1 [cytosol] (Homo sapiens)

Other forms of this molecule

RCE1 [cytosol]

RCE1 [endoplasmic reticulum membrane]

PolyUb-RCE1 [endoplasmic reticulum membrane]

Inferred To

fce-2 [cytosol] (Caenorhabditis elegans)

Sras [cytosol] (Drosophila melanogaster)

Rce1 [cytosol] (Mus musculus)

Rce1 [cytosol] (Rattus norvegicus)

PolyUb-RCE1 [cytosol] (Schizosaccharomyces pombe)

RCE1 [cytosol] (Bos taurus)

RCE1 [cytosol] (Canis familiaris)

RCE1 [cytosol] (Saccharomyces cerevisiae)

RCE1 [cytosol] (Sus scrofa)

Modified Residues

Name

ubiquitinylated lysine (PolyUb [cytosol]) at unknown position

Modification

PolyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_001027450.1, NP_005124.1

Guide to Pharmacology - Targets

2412

OpenTargets

ENSG00000173653

ZINC - Substances

FACE2_HUMAN

HPA

ENSG00000173653-RCE1

GeneCards

Q9Y256

ZINC target

Q9Y256

Ensembl

ENSG00000173653, ENSP00000309163, ENST00000309657

PRO

Q9Y256

Pharos - Targets

Q9Y256

ZINC - Predictions - Purchasable

FACE2_HUMAN

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96RK4 BBS4	1	BBS4 [cytosol] (R-HSA-5617635)	0.508	2

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