Reactome | Binding of acetylcholine to highly calcium permeable acetylcholine receptors

Binding of acetylcholine to highly calcium permeable acetylcholine receptors

Stable Identifier

R-HSA-629599

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

Locations in the PathwayBrowser

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Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - Acetylcholine binding and downstream events (Homo sapiens)
      - Presynaptic nicotinic acetylcholine receptors (Homo sapiens)
        
        Highly calcium permeable nicotinic acetylcholine receptors (Homo sapiens)
        
        Binding of acetylcholine to highly calcium permeable acetylcholine receptors (Homo sapiens)

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Binding of acetylcholine to highly calcium permeable acetylcholine receptors

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Nicotinic acetylcholine receptors bind two molecules of ligand, acetylcholine, in the alpha beta interface in receptors containing heteromeric subunits or in the interface of 2 aplha subunits in receptors containing homomeric subunits.

Literature References

PubMed ID	Title	Journal	Year
19059502	Design and expression of human alpha7 nicotinic acetylcholine receptor extracellular domain mutants with enhanced solubility and ligand-binding properties Zouridakis, M, Zisimopoulou, P, Eliopoulos, E, Poulas, K, Tzartos, SJ	Biochim Biophys Acta	2009