Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors

Stable Identifier
R-HSA-622325
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol, extracellular region
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Nicotinic acetylcholine receptors containing aplha4(2) beta2 (3) and alpha3(2) beta4(3) are selectively highly Na+ permeable upon activation of these receptors by acetylcholine.
Literature References
PubMed ID Title Journal Year
8987816 Human alpha4beta2 neuronal nicotinic acetylcholine receptor in HEK 293 cells: A patch-clamp study

Sullivan, JP, Buisson, B, Bertrand, D, Gopalakrishnan, M, Arneric, SP

J Neurosci 1996
Participants
Input
Output
Participates
as an event of
Catalyst Activity

ligand-gated monoatomic ion channel activity of O-Acetylcholine bound to Acetylcholine receptor [plasma membrane]

Physical Entity
O-Acetylcholine bound to Acetylcholine receptor [plasma membrane] (Homo sapiens)
Activity
ligand-gated monoatomic ion channel activity (GO:0015276)
Orthologous Events
Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors (Bos taurus)
Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors (Caenorhabditis elegans)
Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors (Canis familiaris)
Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors (Drosophila melanogaster)
Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors (Gallus gallus)
Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors (Mus musculus)
Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors (Rattus norvegicus)
Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors (Xenopus tropicalis)
Cross References
Rhea
Authored
Mahajan, SS  (2010-04-27)
Reviewed
Restituito, S  (2008-11-27)
Wen, H  (2020-01-24)
Created
Mahajan, SS  (2010-04-22)
Cite Us!