Reactome | F2RL3(18-385) [plasma membrane]

F2RL3(18-385) [plasma membrane]

Stable Identifier

R-HSA-61315

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Proteinase activated receptor 4, PAR-4, Thrombin receptor- like 3, Coagulation factor II receptor-like 3

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (q) signalling events (Homo sapiens)
      - Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        Thrombin:Proteinase-activated receptors [plasma membrane] (Homo sapiens)
        
        Proteinase-activated receptors [plasma membrane] (Homo sapiens)
        
        F2RL3(18-385) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        Thrombin:Proteinase-activated receptors [plasma membrane] (Homo sapiens)
        
        Proteinase-activated receptors [plasma membrane] (Homo sapiens)
        
        F2RL3(18-385) [plasma membrane] (Homo sapiens)
      - Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        Thrombin:Proteinase-activated receptors [plasma membrane] (Homo sapiens)
        
        Proteinase-activated receptors [plasma membrane] (Homo sapiens)
        
        F2RL3(18-385) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        Thrombin:Proteinase-activated receptors [plasma membrane] (Homo sapiens)
        
        Proteinase-activated receptors [plasma membrane] (Homo sapiens)
        
        F2RL3(18-385) [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
        
        GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        Proteinase-activated receptors [plasma membrane] (Homo sapiens)
        
        F2RL3(18-385) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        Thrombin:Proteinase-activated receptors [plasma membrane] (Homo sapiens)
        
        Proteinase-activated receptors [plasma membrane] (Homo sapiens)
        
        F2RL3(18-385) [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        Proteinase-activated receptors can bind thrombin (Homo sapiens)
        
        Proteinase-activated receptors [plasma membrane] (Homo sapiens)
        
        F2RL3(18-385) [plasma membrane] (Homo sapiens)
        
        Thrombin:Proteinase-activated receptors [plasma membrane] (Homo sapiens)
        
        Proteinase-activated receptors [plasma membrane] (Homo sapiens)
        
        F2RL3(18-385) [plasma membrane] (Homo sapiens)

General

This is the inactive form of the receptor, before protease activation. Proteinase (protease) activated receptors are activated by the cleavage of an N-terminal extracellular segment by serine proteases, particularly thrombin which activates PAR1, 3 and 4. The cleaved fragment is an activating ligand for the receptor; synthetic peptide mimics of the N-terminal fragment can activate uncleaved receptors.

External Reference Information

External Reference

UniProt:Q96RI0 F2RL3

Gene Names

F2RL3, PAR4

Chain

signal peptide:1-17, propeptide:18-47, chain:48-385

Reference Genes

BioGPS Gene:9002 F2RL3

COSMIC (genes):F2RL3 F2RL3

CTD Gene:9002 F2RL3

dbSNP Gene:9002 F2RL3

ENSEMBL:ENSG00000127533 F2RL3

HGNC:3540 F2RL3

KEGG:hsa:9002 F2RL3

Monarch:9002 F2RL3

NCBI Gene:9002 F2RL3

OMIM:602779 F2RL3

UCSC:Q96RI0 F2RL3

Reference Transcript

RefSeq:NM_003950.3 F2RL3

Other Identifiers

11740339_at

11740340_at

16859390

3823958

3823959

3823960

3823961

3823962

3823963

3823964

3823965

8026631

9002

A_14_P106646

A_14_P200527

A_23_P208422

A_33_P3232955

GO:0002020

GO:0004930

GO:0005576

GO:0005886

GO:0007155

GO:0007165

GO:0007186

GO:0007200

GO:0007596

GO:0009611

GO:0015057

GO:0016020

GO:0030168

GO:0035025

GO:0051281

GO:0060089

GO:0060155

GO:0070493

GO:0070527

HMNXSV003010681

ILMN_2127298

TC19000326.hg

Participates

as a member of

Other forms of this molecule

F2RL3(18-47) [extracellular region]

F2RL3 [plasma membrane]

Inferred To

f2rl3 [plasma membrane] (Xenopus tropicalis)

F2rl3 [plasma membrane] (Mus musculus)

F2rl3 [plasma membrane] (Rattus norvegicus)

F2RL3(18-385) [plasma membrane] (Gallus gallus)

F2RL3 [plasma membrane] (Bos taurus)

F2RL3 [plasma membrane] (Canis familiaris)

F2RL3 [plasma membrane] (Sus scrofa)

gnrr-4 [plasma membrane] (Caenorhabditis elegans)

Cross References

RefSeq

NP_003941.2

Guide to Pharmacology - Targets

350

ENSEMBL

ENST00000248076, ENSP00000248076, ENSG00000127533

OpenTargets

ENSG00000127533

ZINC - Substances

PAR4_HUMAN

ZINC target

Q96RI0

PRO

Q96RI0

GlyGen

Q96RI0

PDB

3QDZ, 2ZPK

GeneCards

F2RL3

HPA

ENSG00000127533-F2RL3

Pharos - Targets

Q96RI0

ZINC - Predictions - Purchasable

PAR4_HUMAN

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