F2RL3(18-385)

Stable Identifier
R-HSA-61315
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
Proteinase activated receptor 4, PAR-4, Thrombin receptor- like 3, Coagulation factor II receptor-like 3
Locations in the PathwayBrowser
Summation

This is the inactive form of the receptor, before protease activation. Proteinase (protease) activated receptors are activated by the cleavage of an N-terminal extracellular segment by serine proteases, particularly thrombin which activates PAR1, 3 and 4. The cleaved fragment is an activating ligand for the receptor; synthetic peptide mimics of the N-terminal fragment can activate uncleaved receptors.

External Reference Information
External Reference
Gene Names
F2RL3, PAR4
Chain
signal peptide:1-17, propeptide:18-47, chain:48-385
Reference Transcript
Other Identifiers
11740339_at
11740340_at
16859390
2ZPK
3823958
3823959
3823960
3823961
3823962
3823963
3823964
3823965
3QDZ
8026631
9002
A_14_P200527
A_23_P208422
A_33_P3232955
CCDS12350
ENSG00000127533
ENSP00000248076
ENST00000248076
EntrezGene:9002
F2RL3
F2RL3-201
GO:0004871
GO:0004930
GO:0005576
GO:0005886
GO:0005887
GO:0007165
GO:0007186
GO:0007200
GO:0007596
GO:0007599
GO:0009611
GO:0015057
GO:0016020
GO:0016021
GO:0030168
GO:0035025
GO:0051281
GO:0051482
GO:0060155
GO:0070493
HGNC:3540
ILMN_2127298
MIM:602779
NM_003950
NP_003941
PF00001
PR00237
PR01428
PR01430
TC19000326.hg
uc002nfa.4
UPI000013CC36
Participant Of
Other forms of this molecule
Inferred To
Cross References
RefSeq
ZINC - Substances
GeneCards
DOCK Blaster
ZINC target
PRO
Orphanet
ZINC - Predictions - Purchasable
PDB