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F2RL3 [plasma membrane]
Stable Identifier
R-HSA-114533
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Activated PAR4, Proteinase activated receptor 4
Icon
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Thrombin signalling through proteinase activated receptors (PARs) (Homo sapiens)
Activated thrombin (factor IIa) cleaves PAR3,4, activating them (Homo sapiens)
Thrombin-activated PARs [plasma membrane] (Homo sapiens)
F2RL3 [plasma membrane] (Homo sapiens)
Thrombin-activated PARs activate G12/13 (Homo sapiens)
Thrombin activated PAR:G12/13 (active) [plasma membrane] (Homo sapiens)
Thrombin-activated PARs [plasma membrane] (Homo sapiens)
F2RL3 [plasma membrane] (Homo sapiens)
Thrombin activated PAR:G12/13 (inactive) [plasma membrane] (Homo sapiens)
Thrombin-activated PARs [plasma membrane] (Homo sapiens)
F2RL3 [plasma membrane] (Homo sapiens)
Thrombin-activated PARs [plasma membrane] (Homo sapiens)
F2RL3 [plasma membrane] (Homo sapiens)
Thrombin-activated PARs activate Gq (Homo sapiens)
Thrombin-activated PAR:Gq (active) [plasma membrane] (Homo sapiens)
Thrombin-activated PARs [plasma membrane] (Homo sapiens)
F2RL3 [plasma membrane] (Homo sapiens)
Thrombin-activated PARs [plasma membrane] (Homo sapiens)
F2RL3 [plasma membrane] (Homo sapiens)
Thrombin-activated PARs:Gq (inactive) [plasma membrane] (Homo sapiens)
Thrombin-activated PARs [plasma membrane] (Homo sapiens)
F2RL3 [plasma membrane] (Homo sapiens)
Thrombin-activated PARs binds G-protein G12/13 (Homo sapiens)
Thrombin activated PAR:G12/13 (inactive) [plasma membrane] (Homo sapiens)
Thrombin-activated PARs [plasma membrane] (Homo sapiens)
F2RL3 [plasma membrane] (Homo sapiens)
Thrombin-activated PARs [plasma membrane] (Homo sapiens)
F2RL3 [plasma membrane] (Homo sapiens)
Thrombin-activated PARs binds G-protein Gq (Homo sapiens)
Thrombin-activated PARs [plasma membrane] (Homo sapiens)
F2RL3 [plasma membrane] (Homo sapiens)
Thrombin-activated PARs:Gq (inactive) [plasma membrane] (Homo sapiens)
Thrombin-activated PARs [plasma membrane] (Homo sapiens)
F2RL3 [plasma membrane] (Homo sapiens)
Thrombin-activated PARs:G12/13 (active) dissociate (Homo sapiens)
Thrombin activated PAR:G12/13 (active) [plasma membrane] (Homo sapiens)
Thrombin-activated PARs [plasma membrane] (Homo sapiens)
F2RL3 [plasma membrane] (Homo sapiens)
Thrombin-activated PARs [plasma membrane] (Homo sapiens)
F2RL3 [plasma membrane] (Homo sapiens)
Thrombin-activated PARs:Gq (active) dissociate (Homo sapiens)
Thrombin-activated PAR:Gq (active) [plasma membrane] (Homo sapiens)
Thrombin-activated PARs [plasma membrane] (Homo sapiens)
F2RL3 [plasma membrane] (Homo sapiens)
Thrombin-activated PARs [plasma membrane] (Homo sapiens)
F2RL3 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96RI0 F2RL3
Gene Names
F2RL3, PAR4
Chain
signal peptide:1-17, propeptide:18-47, chain:48-385
Reference Genes
BioGPS Gene:9002 F2RL3
COSMIC (genes):F2RL3 F2RL3
CTD Gene:9002 F2RL3
dbSNP Gene:9002 F2RL3
ENSEMBL:ENSG00000127533 F2RL3
HGNC:3540 F2RL3
KEGG:hsa:9002 F2RL3
Monarch:9002 F2RL3
NCBI Gene:9002 F2RL3
OMIM:602779 F2RL3
UCSC:Q96RI0 F2RL3
Reference Transcript
RefSeq:NM_003950.3 F2RL3
Other Identifiers
11740339_at
11740340_at
16859390
3823958
3823959
3823960
3823961
3823962
3823963
3823964
3823965
8026631
9002
A_14_P106646
A_14_P200527
A_23_P208422
A_33_P3232955
GO:0002020
GO:0004930
GO:0005576
GO:0005886
GO:0007155
GO:0007165
GO:0007186
GO:0007200
GO:0007596
GO:0009611
GO:0015057
GO:0016020
GO:0030168
GO:0035025
GO:0051281
GO:0060089
GO:0060155
GO:0070493
GO:0070527
HMNXSV003010681
ILMN_2127298
TC19000326.hg
Participates
as a member of
Thrombin-activated PARs [plasma membrane] (Homo sapiens)
Other forms of this molecule
F2RL3(18-47) [extracellular region]
F2RL3(18-385) [plasma membrane]
Inferred To
f2rl3 [plasma membrane]
(Xenopus tropicalis)
F2rl3 [plasma membrane]
(Mus musculus)
F2rl3 [plasma membrane]
(Rattus norvegicus)
F2RL3 [plasma membrane]
(Bos taurus)
F2RL3 [plasma membrane]
(Canis familiaris)
F2RL3 [plasma membrane]
(Gallus gallus)
F2RL3 [plasma membrane]
(Sus scrofa)
gnrr-4 [plasma membrane]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_003941.2
Guide to Pharmacology - Targets
350
ENSEMBL
ENST00000248076
,
ENSP00000248076
OpenTargets
ENSG00000127533
HPA
ENSG00000127533-F2RL3
ZINC - Substances
PAR4_HUMAN
ZINC target
Q96RI0
PRO
Q96RI0
Pharos - Targets
Q96RI0
GlyGen
Q96RI0
ZINC - Predictions - Purchasable
PAR4_HUMAN
PDB
3QDZ
,
2ZPK
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