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MT-ND2 [mitochondrial inner membrane]
Stable Identifier
R-HSA-60553
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial inner membrane
Synonyms
NADH-ubiquinone oxidoreductase chain 2 (EC 1.6.5.3)
Icon
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Aerobic respiration and respiratory electron transport (Homo sapiens)
Respiratory electron transport (Homo sapiens)
Complex I biogenesis (Homo sapiens)
COA1:MT-ND2, TMEM186:MT-ND3, MT-ND6, NDUFB6 bind the MCIA complex to form a 370kDa subcomplex (Homo sapiens)
370 kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
COA1:MT-ND2 [mitochondrial inner membrane] (Homo sapiens)
MT-ND2 [mitochondrial inner membrane] (Homo sapiens)
COA1:MT-ND2 [mitochondrial inner membrane] (Homo sapiens)
MT-ND2 [mitochondrial inner membrane] (Homo sapiens)
ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
370 kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
COA1:MT-ND2 [mitochondrial inner membrane] (Homo sapiens)
MT-ND2 [mitochondrial inner membrane] (Homo sapiens)
815kDa complex [mitochondrial inner membrane] (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
370 kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
COA1:MT-ND2 [mitochondrial inner membrane] (Homo sapiens)
MT-ND2 [mitochondrial inner membrane] (Homo sapiens)
Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Homo sapiens)
815kDa complex [mitochondrial inner membrane] (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
370 kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
COA1:MT-ND2 [mitochondrial inner membrane] (Homo sapiens)
MT-ND2 [mitochondrial inner membrane] (Homo sapiens)
980kDa complex [mitochondrial inner membrane] (Homo sapiens)
815kDa complex [mitochondrial inner membrane] (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
370 kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
COA1:MT-ND2 [mitochondrial inner membrane] (Homo sapiens)
MT-ND2 [mitochondrial inner membrane] (Homo sapiens)
The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Homo sapiens)
370 kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
COA1:MT-ND2 [mitochondrial inner membrane] (Homo sapiens)
MT-ND2 [mitochondrial inner membrane] (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
370 kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
COA1:MT-ND2 [mitochondrial inner membrane] (Homo sapiens)
MT-ND2 [mitochondrial inner membrane] (Homo sapiens)
The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Homo sapiens)
980kDa complex [mitochondrial inner membrane] (Homo sapiens)
815kDa complex [mitochondrial inner membrane] (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
370 kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
COA1:MT-ND2 [mitochondrial inner membrane] (Homo sapiens)
MT-ND2 [mitochondrial inner membrane] (Homo sapiens)
Complex I [mitochondrial inner membrane] (Homo sapiens)
815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
370 kDa subcomplex (-MCIA complex) [mitochondrial inner membrane] (Homo sapiens)
COA1:MT-ND2 [mitochondrial inner membrane] (Homo sapiens)
MT-ND2 [mitochondrial inner membrane] (Homo sapiens)
Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 (Homo sapiens)
Complex I [mitochondrial inner membrane] (Homo sapiens)
815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
370 kDa subcomplex (-MCIA complex) [mitochondrial inner membrane] (Homo sapiens)
COA1:MT-ND2 [mitochondrial inner membrane] (Homo sapiens)
MT-ND2 [mitochondrial inner membrane] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Mitochondrial protein degradation (Homo sapiens)
YME1L1 binds mitochondrial inner membrane proteins (Homo sapiens)
Substrate of YME1L1 (mitochondrial inner membrane) [mitochondrial inner membrane] (Homo sapiens)
MT-ND2 [mitochondrial inner membrane] (Homo sapiens)
YME1L1:substrate protein (mitochondrial inner membrane) [mitochondrial inner membrane] (Homo sapiens)
Substrate of YME1L1 (mitochondrial inner membrane) [mitochondrial inner membrane] (Homo sapiens)
MT-ND2 [mitochondrial inner membrane] (Homo sapiens)
YME1L1 degrades mitochondrial inner membrane proteins (Homo sapiens)
YME1L1:substrate protein (mitochondrial inner membrane) [mitochondrial inner membrane] (Homo sapiens)
Substrate of YME1L1 (mitochondrial inner membrane) [mitochondrial inner membrane] (Homo sapiens)
MT-ND2 [mitochondrial inner membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P03891 MT-ND2
Gene Names
MT-ND2, MTND2, NADH2, ND2
Chain
chain:1-347
Reference Genes
BioGPS Gene:4536 MT-ND2
COSMIC (genes):MT-ND2 MT-ND2
CTD Gene:4536 MT-ND2
dbSNP Gene:4536 MT-ND2
ENSEMBL:ENSG00000198763 MT-ND2
HGNC:7456 MT-ND2
KEGG:hsa:4536 MT-ND2
Monarch:4536 MT-ND2
NCBI Gene:4536 MT-ND2
OMIM:516001 MT-ND2
UCSC:P03891 MT-ND2
Reference Transcript
RefSeq:NC_012920.1 MT-CYB
Other Identifiers
11762992_at
1553551_3p_s_at
1553551_PM_s_at
1553551_s_at
17100649
17100651
17100653
17100655
17100657
2315227
2315229
2315305
2315306
2315307
2315308
2315309
2315310
3560048
3990047
4037603
4037605
4037607
4037609
4037610
4037611
4037612
4037614
4037616
4037618
4037620
4037622
4037624
4037625
4536
7896746
7896748
8165656
8165658
ADDON000548.hg
ADDON001198.hg
A_23_P431853
GO:0001666
GO:0003824
GO:0005215
GO:0005515
GO:0005739
GO:0005743
GO:0006091
GO:0006120
GO:0008137
GO:0009060
GO:0016491
GO:0019901
GO:0032981
GO:0035255
GO:0042776
GO:0043226
GO:0045271
GO:0055085
GO:0055086
GO:0065003
GO:0072593
GO:1901135
GO:1902600
HMNXSV003044876
Hs2Affx.1.29.S1_3p_s_at
RNA143501|tRNA_418_69
TC01004109.hg
TC0M000004.hg
Participates
as a member of
Substrate of YME1L1 (mitochondrial inner membrane) [mitochondrial inner membrane] (Homo sapiens)
as a component of
COA1:MT-ND2 [mitochondrial inner membrane] (Homo sapiens)
Inferred To
mt-nd2 [mitochondrial inner membrane]
(Danio rerio)
mt-nd2 [mitochondrial inner membrane]
(Xenopus tropicalis)
Mt-nd2 [mitochondrial inner membrane]
(Rattus norvegicus)
Ghost homologue of MT-ND2 [mitochondrial inner membrane]
(Caenorhabditis elegans)
Ghost homologue of MT-ND2 [mitochondrial inner membrane]
(Canis familiaris)
mt-Nd2 [mitochondrial inner membrane]
(Mus musculus)
MT-ND2 [mitochondrial inner membrane]
(Bos taurus)
MT-ND2 [mitochondrial inner membrane]
(Gallus gallus)
MT-ND2 [mitochondrial inner membrane]
(Sus scrofa)
mt:ND2 [mitochondrial inner membrane]
(Drosophila melanogaster)
Cross References
ENSEMBL
ENST00000361453
,
ENSP00000355046
,
ENSG00000198763
OpenTargets
ENSG00000198763
GeneCards
MT-ND2
HPA
ENSG00000198763-MT-ND2
PRO
P03891
Pharos - Targets
P03891
Orphanet
MT-ND2
HMDB Protein
HMDBP00154
PDB
5XTI
,
5XTH
,
5XTC
,
5XTD
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O75380 NDUFS6
1
NDUFS6 [mitochondrial inner membrane]
(R-HSA-163922)
0.527
3
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