Reactome | mt:ND2 [mitochondrial inner membrane]

mt:ND2 [mitochondrial inner membrane]

Stable Identifier

R-DME-60553

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

mitochondrial inner membrane

Synonyms

MT-ND2, P03896

Locations in the PathwayBrowser

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Metabolism (Drosophila melanogaster)

- Aerobic respiration and respiratory electron transport (Drosophila melanogaster)
  - Respiratory electron transport (Drosophila melanogaster)
    - Complex I biogenesis (Drosophila melanogaster)
      - The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Drosophila melanogaster)
        
        370 kDa subcomplex [mitochondrial inner membrane] (Drosophila melanogaster)
        
        COA1:MT-ND2 [mitochondrial inner membrane] (Drosophila melanogaster)
        
        mt:ND2 [mitochondrial inner membrane] (Drosophila melanogaster)
        
        550kDa complex [mitochondrial inner membrane] (Drosophila melanogaster)
        
        370 kDa subcomplex [mitochondrial inner membrane] (Drosophila melanogaster)
        
        COA1:MT-ND2 [mitochondrial inner membrane] (Drosophila melanogaster)
        
        mt:ND2 [mitochondrial inner membrane] (Drosophila melanogaster)
      - The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Drosophila melanogaster)
        
        980kDa complex [mitochondrial inner membrane] (Drosophila melanogaster)
        
        815kDa complex [mitochondrial inner membrane] (Drosophila melanogaster)
        
        550kDa complex [mitochondrial inner membrane] (Drosophila melanogaster)
        
        370 kDa subcomplex [mitochondrial inner membrane] (Drosophila melanogaster)
        
        COA1:MT-ND2 [mitochondrial inner membrane] (Drosophila melanogaster)
        
        mt:ND2 [mitochondrial inner membrane] (Drosophila melanogaster)
        
        Complex I [mitochondrial inner membrane] (Drosophila melanogaster)
        
        815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Drosophila melanogaster)
        
        550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Drosophila melanogaster)
        
        370 kDa subcomplex (-MCIA complex) [mitochondrial inner membrane] (Drosophila melanogaster)
        
        COA1:MT-ND2 [mitochondrial inner membrane] (Drosophila melanogaster)
        
        mt:ND2 [mitochondrial inner membrane] (Drosophila melanogaster)
    - Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 (Drosophila melanogaster)
      - Complex I [mitochondrial inner membrane] (Drosophila melanogaster)
        
        815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Drosophila melanogaster)
        
        550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Drosophila melanogaster)
        
        370 kDa subcomplex (-MCIA complex) [mitochondrial inner membrane] (Drosophila melanogaster)
        
        COA1:MT-ND2 [mitochondrial inner membrane] (Drosophila melanogaster)
        
        mt:ND2 [mitochondrial inner membrane] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:P03896

Gene Names

mt:ND2

Reference Genes

BioGPS Gene:19893529 mt:ND2

ENSEMBL:FBgn0013680

FlyBase:FBgn0013680

KEGG:dme:Dmel_CG34063 mt:ND2

Monarch:19893529 mt:ND2

NCBI Gene:19893529 mt:ND2

UCSC:P03896 mt:ND2

Reference Transcript

RefSeq:NC_024511.2 mt:ND3

Other Identifiers

192474

19893529

GO:0005739

GO:0005743

GO:0005747

GO:0006091

GO:0006120

GO:0008137

GO:0016020

GO:0016491

GO:0045271

GO:0055085

GO:0070469

GO:1902600

Participates

as a member of

MT-ATP6,MT-ATP8,MT-CO2,MT-CO3,MT-CYB,MT-ND1,MT-ND2,MT-ND3,MT-ND4,MT-ND4L,MT-ND5 [mitochondrial inner membrane] (Drosophila melanogaster)

as a component of

COA1:MT-ND2 [mitochondrial inner membrane] (Drosophila melanogaster)

Inferred From

MT-ND2 [mitochondrial inner membrane] (Homo sapiens)

Cross References

RefSeq

YP_009047266.1

ENSEMBL

FBpp0100175, FBtr0100857, FBgn0013680

IntEnz

7.1.1.2

FlyBase

FBgn0013680

PRO

P03896

PDB

8BA0, 8B9Z, 8ESZ, 8ESW