Reactome | MICA [plasma membrane]

MICA [plasma membrane]

Stable Identifier

R-HSA-5696432

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

MHC class I polypeptide-related sequence A, MICA_HUMAN

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External Reference Information

External Reference

UniProt:Q29983 MICA

Gene Names

MICA, PERB11.1

Chain

signal peptide:1-23, chain:24-383

Reference Genes

BioGPS Gene:100507436 MICA

COSMIC (genes):MICA MICA

CTD Gene:100507436 MICA

dbSNP Gene:100507436 MICA

HGNC:7090 MICA

Monarch:100507436 MICA

NCBI Gene:100507436 MICA

OMIM:600169 MICA

UCSC:Q29983 MICA

Reference Transcript

RefSeq:NM_000247.2 MICA

Other Identifiers

100507436

11738887_s_at

11738888_x_at

11763217_x_at

17006590

17027725

17033279

17038059

17040647

205904_PM_at

205904_at

205905_PM_s_at

205905_s_at

2902284

2902287

2902288

2902289

2902293

2902294

2902295

2902296

2902297

2902298

2902299

2902300

2902303

2902304

2902305

2902349

40755_at

8118100

8179238

A_23_P257516

A_33_P3368452

A_33_P3368453

GE60158

GO:0001913

GO:0001916

GO:0002250

GO:0002376

GO:0002418

GO:0002476

GO:0002486

GO:0005102

GO:0005515

GO:0005615

GO:0005737

GO:0005886

GO:0006955

GO:0006974

GO:0007165

GO:0009408

GO:0009897

GO:0009986

GO:0016020

GO:0031640

GO:0032815

GO:0042267

GO:0042605

GO:0042742

GO:0045953

GO:0046629

GO:0046703

GO:0048018

GO:0051607

GO:0098542

GO:0098772

HMNXSV003030995

ILMN_1797929

L14848_s_at

PH_hs_0029035

PH_hs_0031456

TC06002708.hg

TC06004073.hg

TC6_cox_hap2000234.hg

TC6_mann_hap4000215.hg

TC6_qbl_hap6000238.hg

TC6_ssto_hap7000188.hg

g4557750_3p_at

p33712

Participates

as a member of

NKG2D ligand [plasma membrane] (Homo sapiens)

Inferred To

mhc1zda [plasma membrane] (Danio rerio)

mhc1zea [plasma membrane] (Danio rerio)

mhc1-uba15 [plasma membrane] (Xenopus tropicalis)

mhc1zca [plasma membrane] (Danio rerio)

MICA [plasma membrane] (Bos taurus)

MICA [plasma membrane] (Gallus gallus)

MICA [plasma membrane] (Sus scrofa)

mhc1uba [plasma membrane] (Danio rerio)

LOC100490728 [plasma membrane] (Xenopus tropicalis)

mhc1zba [plasma membrane] (Danio rerio)

mhc1zfa [plasma membrane] (Danio rerio)

BF1 [plasma membrane] (Gallus gallus)

mhc1uma [plasma membrane] (Danio rerio)

BFIV21 [plasma membrane] (Gallus gallus)

mhc1-uda [plasma membrane] (Xenopus tropicalis)

mhc1-uea [plasma membrane] (Xenopus tropicalis)

mhc1-uba13.5 [plasma membrane] (Xenopus tropicalis)

MIC2 [plasma membrane] (Bos taurus)

mhc1laa [plasma membrane] (Danio rerio)

Homologues of MICA [plasma membrane] (Bos taurus)

Homologues of MICA [plasma membrane] (Danio rerio)

Homologues of MICA [plasma membrane] (Gallus gallus)

Homologues of MICA [plasma membrane] (Sus scrofa)

Homologues of MICA [plasma membrane] (Xenopus tropicalis)

mr1l [plasma membrane] (Xenopus tropicalis)

Cross References

ENSEMBL

ENSP00000383179, ENSP00000446963, ENST00000418465, ENST00000547609, ENSP00000402134, ENST00000400325

OpenTargets

ENSG00000204520

PRO

Q29983

Pharos - Targets

Q29983

PDB

8TM2, 7FI5, 1B3J, 8TLZ, 7FI8, 7FI6, 7FI7, 8TM0, 7FI9, 1HYR

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q01523 DEFA5	5	DEFA5(1-94) [Golgi lumen] (R-HSA-1467267) DEFA5(20-94) [Golgi lumen] (R-HSA-1467208) DEFA5(20-94) [secretory granule lumen] (R-HSA-1471358) DEFA5(20-94) [extracellular region] (R-HSA-1471344) DEFA5(?-94) [extracellular region] (R-HSA-1462017)	0.527	2
UniProt:Q15836 VAMP3	6	VAMP3 [recycling endosome membrane] (R-HSA-2029063) VAMP3 [phagocytic vesicle membrane] (R-HSA-2029013) VAMP3 [plasma membrane] (R-HSA-8867599) VAMP3 [trans-Golgi network membrane] (R-HSA-6814624) VAMP3 [transport vesicle] (R-HSA-6814625) VAMP3 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869130)	0.527	2
UniProt:P17931 LGALS3	3	LGALS3 [ficolin-1-rich granule membrane] (R-HSA-6803307) LGALS3 [plasma membrane] (R-HSA-879445) LGALS3 [secretory granule membrane] (R-HSA-6803327)	0.524	2

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