Reactome | PXLP-K278-PHYKPL tetramer hydrolyses 5PHL

PXLP-K278-PHYKPL tetramer hydrolyses 5PHL

Stable Identifier

R-HSA-5696408

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

5R)-5-phosphooxy-L-lysine + H2O => (S)-2-amino-6-oxohexanoate + NH4(+) + phosphate

ReviewStatus

5/5

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PXLP-K278-PHYKPL tetramer hydrolyses 5PHL

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In mitochondria, ethanolamine-phosphate phospho-lyase and 5-phosphohydroxy-L-lysine phospho-lyase (ETNPPL and PHYKPL respectively) are two closely related pyridoxal-phosphate-dependent, homotetrameric ammoniophospholyases that hydrolyse phosphoethanolamine (PETA) and 5-phosphohydroxylysine (5PHL) respectively (Veiga-da-Cunha et al. 2012). PETA is a component and a precursor of phospholipids whereas 5PHL is a breakdown product of collagen. ETNPPL utilises one pyridoxal 5'-phosphate (PXLP) as cofactor per subunit.

Literature References

PubMed ID	Title	Journal	Year
22241472	Molecular identification of hydroxylysine kinase and of ammoniophospholyases acting on 5-phosphohydroxy-L-lysine and phosphoethanolamine Veiga-da-Cunha, M, Hadi, F, Balligand, T, Stroobant, V, Van Schaftingen, E	J. Biol. Chem.	2012