Bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) (NUDT2) mediates the asymmetrical hydrolysis of P(1),P(4)-bis(5'-guanosyl) tetraphosphate (GP4G) to yield AMP and ATP. GP4G is implicated in the regulation of cellular responses to stress and its hydrolysis could serve as a mechanism by which homeostasis is maintained by preventing its build-up (Thorne et al. 1995, Swarbrick et al. 2005).
Hankin, S, Barraclough, R, Thorne, NM, Nuñez, C, McLennan, AG, Wilkinson, MC
Gunawardana, D, Gayler, KR, Swarbrick, JD, Gooley, PR, Buyya, S, McLennan, AG
bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity of NUDT2 [mitochondrial matrix]
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