NUDT2 hydrolyses GP4G to GTP, GMP

Stable Identifier
R-HSA-5696197
Type
Reaction
Species
Homo sapiens
Compartment
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Bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) (NUDT2) mediates the asymmetrical hydrolysis of P(1),P(4)-bis(5'-guanosyl) tetraphosphate (GP4G) to yield AMP and ATP. GP4G is implicated in the regulation of cellular responses to stress and its hydrolysis could serve as a mechanism by which homeostasis is maintained by preventing its build-up (Thorne et al. 1995, Swarbrick et al. 2005).

Literature References
PubMed ID Title Journal Year
7487923 Human diadenosine 5',5"'-P1,P4-tetraphosphate pyrophosphohydrolase is a member of the MutT family of nucleotide pyrophosphatases

Hankin, S, Barraclough, R, Thorne, NM, Nuñez, C, McLennan, AG, Wilkinson, MC

Biochem. J. 1995
15596429 Structure and substrate-binding mechanism of human Ap4A hydrolase

Gunawardana, D, Gayler, KR, Swarbrick, JD, Gooley, PR, Buyya, S, McLennan, AG

J. Biol. Chem. 2005
Participants
Participates
Catalyst Activity

bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity of NUDT2 [mitochondrial matrix]

Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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