Reactome | NUDT2 hydrolyses GP4G to GTP, GMP

NUDT2 hydrolyses GP4G to GTP, GMP

Stable Identifier

R-HSA-5696197

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial matrix

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Bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) (NUDT2) mediates the asymmetrical hydrolysis of P(1),P(4)-bis(5'-guanosyl) tetraphosphate (GP4G) to yield AMP and ATP. GP4G is implicated in the regulation of cellular responses to stress and its hydrolysis could serve as a mechanism by which homeostasis is maintained by preventing its build-up (Thorne et al. 1995, Swarbrick et al. 2005).

Literature References

PubMed ID	Title	Journal	Year
15596429	Structure and substrate-binding mechanism of human Ap4A hydrolase Swarbrick, JD, Buyya, S, Gunawardana, D, Gayler, KR, McLennan, AG, Gooley, PR	J. Biol. Chem.	2005
7487923	Human diadenosine 5',5"'-P1,P4-tetraphosphate pyrophosphohydrolase is a member of the MutT family of nucleotide pyrophosphatases Thorne, NM, Hankin, S, Wilkinson, MC, Nuñez, C, Barraclough, R, McLennan, AG	Biochem. J.	1995